Registration Dossier
Registration Dossier
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EC number: 220-585-8 | CAS number: 2825-82-3
Endpoint summary
Administrative data
Description of key information
QSAR results (K1) are available to assess the aquatic toxicity of the registered substance.
To assess the short-term toxicity to aquatic invertebrate, algae and fish, three reliable QSAR results are available.The QSAR predictions (iSafeRat holistic approach v1.7 and v1.8) has been validated to be compliant with the OECD recommendations for QSAR modeling (OECD, 2004) and predict the ecotoxicological values which would be expected when testing the substance under experimental conditions in a laboratory following OECD Guidelines. The ecotoxicological predictions were determined using a validated QSAR for the Mode of Action in question, (MOA 1 or MechoA 1.1, non-polar narcosis) (Bauer et al. 2018). This QSAR is based on validated data for training sets for which the concentrations of the test substance had been determined by chemical analyses over the test period. According to these predictions, ecotoxicological data are the following:
- aquatic invertebrates: 48h-EC50 based on mobility was determined to be 1.0 mg/L (95% CL: 0.37 - 2.87 mg/L),
- algae: 72-h ErC50 based on growth rate was determined to be 0.92 mg/L (95% CL: 0.29 - 2.87 mg/L),
- fish: 96-h LC50 based on mortality was determined to be 0.87 mg/L (95%CL: 0.26 - 2.9 mg/L),
To assess the toxicity to microorganisms, one QSAR study is available on the registered substance wih a 30-180 min EC50 of THDCPD to activated sludge greater than the water solubility value within the exposure period of the test.
The substance falls within the applicability domain of the model.
Bauer F., Thomas, P., Fouchard S., Neunlist S., 2018. High-accuracy prediction of mechanisms of action using structural alerts. Computational Toxicology 7:36 -45
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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