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EC number: 614-626-2
CAS number: 685853-81-0
Expert Group on Vitamins and Minerals (EGVM) also concluded that overall
there are insufficient data from human and animals studies to derive a
safe upper level for chromium. However, in the opinion of the EGVM a
total daily intake of about 0.15 mg trivalent chromium per kg body
weight and day (or 10 mg/person) would be expected to be without adverse
health effects. This value uses a 100-fold margin of safety on a study
which indicates that 15 mg trivalent chromium/kg bw/day is not
associated with adverse effects in the rat.
Committee on Medical Aspects of Food Policy calculated a theoretical
requirement for adults from balance studies of 23 µg/day by using
regression equations and concluded that a safe and adequate level of
intake lies above 25 µg for adults and between 0.1 - 1
µg/kg bw/day for children and adolescents, respectively
deficiency has only been seen in humans in extreme cases and as part of
general malnutrition. Symptoms
have been shown to include impaired glucose tolerance and glucose
utilisation, weight loss, neuropathy, elevated plasma fatty acids,
depressed respiratory quotient and abnormalities in nitrogen metabolism. The
symptoms disappeared rapidly after oral supplementation of 200 µg/day.
acid and associated salts are found in many foods and are formed in
cells as a metabolite from glycolysis. There is no toxicity theshold
for repeated exposure in humans, although acute toxic effects have been
reported in animals. The reported toxicity thresholds for anhydrous
citric acid appear in part due to effects of an irritant acid.
in rats showed a similar glucose intolerance and other signs in animals
include impaired growth, elevated serum cholesterol and triglycerides,
increased incidence of aortic plaques, corneal lesions and decreased
fertility and sperm count.
considered that supplementation of chromium should not exceed 250 µg/day
dietary chromium III intake is in the ranges of 60–170 μg/day
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