Registration Dossier

Toxicological information

Endpoint summary

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Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (sensitising)
Additional information:

The test substance 1,8-naphylenediamine was evaluated for potential skin sensitizing properties in a maximisation test as decribed by Magnusson and Kligman. The test was performed on male guinea pigs. The following test compound concentrations were used in this test:

Intradermal induction: 5 %

Topical induction: 50 %

Challenge: 50% and 25 %

After the challenge with a 50% suspension all animals revealed a positive reaction, and after the challenge with a 25% suspension 80% of the animals revealed a positive reaction. In the control group no reaction was observed.

Therefore a classification as Xi, R43 (GHS: Skin Sens.1B) ist justified.


Migrated from Short description of key information:
In a valid study 1,8-naphthylenediaminewas tested in a guinea pig maximisation test (GPMT) as described by Magnusson and Kligman

Justification for selection of skin sensitisation endpoint:
Key study used

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available
Additional information:

no data

Justification for classification or non-classification

In the skin sensitization test according Magnusson and Kligman, after the challenge with a 50% suspension 100% of the animals revealed a positive reaction, and after the challenge with a 25% suspension 80% of the animals revealed a positive reaction. In the control group no reaction was observed.

Therefore a classification as Xi, R43 (GHS: Skin Sens.1B) ist justified.