Tetraammonium decachloro-μ-oxodiruthenate(4-)

Particle size distribution (Granulometry)

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

4 October 2010 to 21 December 2010

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)

Version / remarks:

Screening Test

Principles of method if other than guideline:

The method used is based on a procedure designed to comply with that given in 'Particle size distribution, fibre length and diameter distribution', June 1996 European Commission technical guidance document, which satisfies the requirements of OECD Guideline 110

GLP compliance:

yes (incl. QA statement)

Type of method:

sieving

Type of particle tested:

primary particle

Type of distribution:

mass based distribution

No.:

#1

Size:

< 100 µm

Distribution:

0 %

The results of the sieving procedure are shown below:

Measurement	Result
Mass of test item transferred to sieve	10.36g
Mass of test item passed through sieve	0g
Proportion of test item <100µm	0%

Conclusions:

The proportion of tetraammonium decachloro-mu-oxodiruthenate (4-) <100 μm was 0%.

Executive summary:

Tremain and Atwal (2011) is a GLP compliant study following OECD guideline 110 (screening test) and is considered suitable for use as the key study for this endpoint. The proportion of tetraammonium decachloro-mu-oxodiruthenate (4-) < 100 μm was 0%

Reference 2

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

Non-GLP, guideline study, well reported, reliable without restrictions

Qualifier:

according to guideline

Guideline:

DIN 55992-1 (Determination of a parameter for the dust formation of pigments and extenders - Part 1: Rotation method)

Deviations:

no

GLP compliance:

no

Type of method:

rotating drum method

Remarks:

modified Heubach procedure

Type of particle tested:

other: dust particles

Type of distribution:

mass based distribution

Mass median aerodynamic diameter:

28.96 µm

Geometric standard deviation:

2.21

Experimental results

Quantity of substance used [g]: 1

Total dust mass in impactor [mg]: 341.3

Dust concentration in impactor [mg/m³]: 1711.00

Total dustiness [mg/g]: 341.30

Inhalable fraction [mg/g]: 207.74

Thoracic fraction [mg/g]: 46.94

Respirable fraction [mg/g]: 8.61

Mass Median Aerodynamic Diameter (MMAD) = 28.96 μm (GSD = 2.21 μm)

Conclusions:

The total dustiness of Diammonium hexachlororuthenate was determined to be 341.30 mg/g. The inhalable fraction was 207.74 mg/g, the thoracic fraction was 46.94 mg/g and the respirable fraction was 8.61 mg/g. The Mass Median Aerodynamic Diameter (MMAD) was 28.96 μm with Geometric Standard Deviation of 2.21 μm.

Executive summary:

The dustiness of Diammonium hexachlororuthenate was tested in a modified Heubach procedure accordingt o the guideline DIN 55992-1:2006 'Determination of a parameter for the dust formation of pigments and extenders - Part 1: Rotation method'. The substance was mechanically stressed in a rotating drum and the airborne dust was fed into a seven-stage cascade impactor. The dust masses collected at each cascade stage were weighed to determine total dustiness. Dust from 1.00 g of sample was generated for 5 min at a temperature of 25.5 ºC, 55.6 % relative humidity and 1003.0 hPa atmosphere. The dustiness values in accordance with DIN EN 481 were calculated from the particle size distribution determined (cumulative frequency distribution) with the help of an excel macro. The study is non-GLP, but follows a standard guideline and is considered to be reliable. The total dustiness of Diammonium hexachlororuthenate was determined to be 341.30 mg/g. The inhalable fraction was 207.74 mg/g, the thoracic fraction was 46.94 mg/g and the respirable fraction was 8.61 mg/ g. The Mass Median Aerodynamic Diameter (MMAD) was 28.96 μm with Geometric Standard Deviation of 2.21 μm.

Description of key information

The proportion of tetraammonium decachloro-mu-oxodiruthenate (4-) <100 μm was 0 %.

Additional information

Tremain and Atwal (2011) is a GLP compliant study following OECD guideline 110 (screening test) and is considered suitable for use as the key study for this endpoint. The proportion of tetraammonium decachloro-mu-oxodiruthenate (4-) < 100 μm was 0%.

 

In the dustiness test, the substance was identified as diammonium hexachlororuthenate in the test report. The substance identity is equivalent to tetraammonium decachloro-mu-oxodiruthenate(4-). The substance was tested in a modified Heubach procedure according to the guideline DIN 55992-1:2006 (Selck and Parr 2011). The study is non-GLP, but follows a standard guideline and is considered to be reliable. The total dustiness of the test item was determined to be 341.30 mg/g. The inhalable fraction was 207.74 mg/g, the thoracic fraction was 46.94 mg/g and the respirable fraction was 8.61 mg/ g. The Mass Median Aerodynamic Diameter (MMAD) was 28.96 μm with Geometric Standard Deviation of 2.21 μm.