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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

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Physical & Chemical properties

Partition coefficient

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2010-01-13
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods with acceptable restrictions
Remarks:
Test procedure in accordance with national standard methods (ASTM) without GLP.
Qualifier:
according to guideline
Guideline:
other: ASTM E 1147
Deviations:
no
GLP compliance:
no
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
> 15
Temp.:
20 °C
pH:
ca. 7

Measurement

Log Kow: >15.0

Conclusions:
A log Kow value of >15 was obtained for the substance using a relevant test method. The result is considered to be reliable.
Executive summary:

Tetracosanol was determined according ASTM E 1147. The partition coefficient was determined to be log Pow >15.

Description of key information

The octanol-water log partition coefficient of tetracosan-1-ol is >15  (by HPLC method). A log Kow value of 7.75 is estimated for the pure alcohol based on the realistic limitations of experimental results in the shake-flask test and by reference to the trends observed for structural analogues within the chemical Category.

Key value for chemical safety assessment

Log Kow (Log Pow):
15
at the temperature of:
20 °C

Additional information

The log partition coefficient of >15 was determined for the substance in a reliable study.

It is supported by a value of 7.75 based on the realistic limitations of experimental results in the shake-flask test and by reference to the properties of structural analogues within the chemical Category. The quantified estimate is used in environmental modelling.

Discussion of trends in the Category of C6-24 linear and essentially-linear aliphatic alcohols:

As chain length increases, the free energy required for a molecule to dissolve becomes less favourable for larger molecules. The octanol-water partition coefficient increases with molecular weight because each additional -CH2- group makes the octanol phase more preferred over water in terms of relative solvation energy.