Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

GLP guideline study showing very slight erythema to rabbit skin (OECD 404)  
Non-GLP study reporting increased irritation response over 7 days after 24 hour exposure to the test substance

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

Dermal Irritation

Longer exposure to the test material in the non-GLP study produced higher scores for erythema and oedema and showed an increasing effect over the first 7 days after exposure. However, no effect was attributed to abrasion of skin and the effects were largely reversible within 14 days. A recent GLP study conducted in accordance with the recognised guideline reported very mild irritation, which was fully reversible within 7 days.

Eye Irritation

A recent GLP study conducted in accordance with the recognised guideline reported conjunctival irritation that resolved within 72 hours. The results confirmed those reported in a previous non-GLP study.


Effects on skin irritation/corrosion: slightly irritating

Effects on eye irritation: slightly irritating

Justification for classification or non-classification

SKIN IRRITATION

Results from a modern GLP guideline study did not indicate significant inflammation of the skin under the terms of Directive 67/548/EEC or Regulation (EC) 1272/2008. No classification is therefore warranted under GHS/CLP.

EYE IRRITATION

Results from a modern GLP guideline study did not indicate significant eye inflammation under the terms of Directive 67/548/EEC or Regulation (EC) 1272/2008. No classification is therefore warranted under GHS/CLP.