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EC number: 203-467-0 | CAS number: 107-14-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1984
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute toxicities of organic chemicals to fathead minnows (pimephales promelas), Vol 1
- Author:
- Brooke LT, Call DJ, Geiger DL, Northcott CE (eds)
- Year:
- 1 984
- Bibliographic source:
- Center for Lake Superior Studies, University of Wisconsin-Superior. ISBN 0-9614968-0-0
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: US EPA method E03-05
- Deviations:
- not specified
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Chloroacetonitrile
- EC Number:
- 203-467-0
- EC Name:
- Chloroacetonitrile
- Cas Number:
- 107-14-2
- Molecular formula:
- C2H2ClN
- IUPAC Name:
- 2-chloroacetonitrile
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Pimephales promelas
- Details on test organisms:
- TEST ORGANISM
- Common name: fathead minnows were cultured from brood stock
- Source: USEPA Environmental Research Laboratory (Duluth).
- Age at study initiation: Adults 32 day-old
- Length at study initiation: mean length of 18.6 mm (SD=2.393)
- Weight at study initiation: 0.106 g (SD=0.0385)
- Feeding:
- Food type: adult brine shrimp (Artemia). Fry were fed freshly hatched brine shrimp nauplii.
- Frequency: Fry were fed three times daily until 24-h before test start. Fish were not fed during exposure.
-other: held in a flow through system before use.
Study design
- Test type:
- flow-through
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- 45.5 mg/l as CaCO3. Measured using an EDTA method
- Test temperature:
- 26.1 (SD=0.24) degC. Measured daily using a mercury thermometer. Target 25C.
- pH:
- 7.75 (SD=0.1). Alkalinity 41.5 mg/l as CaCO3 by titration method.
- Dissolved oxygen:
- 6.5 (SD=0.32) mg/l. Measured 3x during test using an O2 electrode.
- Salinity:
- not applicable
- Nominal and measured concentrations:
- 1.3, 2.0, 3.1, 4.7 and 7.2 mg/l.
- Details on test conditions:
- TEST SYSTEM
- Material, size, headspace, fill volume: The tank volume was 1l
- No. of organisms per vessel: 20 fish
- Type of flow-through (e.g. peristaltic or proportional diluter): cycling proportional diluter (Mount, Water Res, 1, 21-9, 1967)
- Biomass loading rate: 1.409 g/l
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Lake Superior water
- Metals: Na~1.1mg/l; Ca~14mg/l; K~0.5mg/l; Mg~3mg/l; Al 1-26ug/l; Cr 2-20ug/l; Cu 0.3-3.2ug/l; Fe 2-83ug/l; Pb 7-20ug/l; Mn 0.2-11.5ug/l; Zn 1-2.7ug/l; Ni, Co<0.5ug/l; Cd<0.1ug/l
- Chloride: ~1.25 mg/l
- Ca/mg ratio:~28
- Conductivity: ~80umhos/cm
- Culture medium different from test medium: no
- Intervals of water quality measurement: results of measurements over a number of years (1980-83)
OTHER TEST CONDITIONS
- Photoperiod: 16 h light/dark photoperiod. - Reference substance (positive control):
- no
Results and discussion
Effect concentrations
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 1.35 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 95% CI = 1.15 - 1.58
- Details on results:
- Fish continued to die even upon termination of the test (in the lowest exposure concentration).
- Results with reference substance (positive control):
- not applicable
- Reported statistics and error estimates:
- no data
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- In a well reported 96 hour acute toxicity study, fathead minnows (Pimephales promelas) were exposed to the test substance at concentrations up to 7.2 mg/l using a flow through method. An LC50 of 1.35 mg/l was established.
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