Registration Dossier
Registration Dossier
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EC number: 204-274-4 | CAS number: 118-75-2
Endpoint summary
Administrative data
Description of key information
Skin irritation
KEY_404_1989_Hoechst_89.0506: not irritating
Eye irritation
KEY_405_1975_Hoechst_637/75: Risk of serious damage to eyes.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Effects on eye irritation: highly irritating
Justification for classification or non-classification
This substance is classified in Annex VI of Regulation (EC) No 1272/2008 as Eye Irrit. Cat 2, H319, Skin Irrit. Cat 2, H315 and Xi; R36/38. Available data presented in this IUCLID would justify a deviating classsification:
Skin irritation:
No classification, based on calculeted erythema and edema scores (mean of 24, 48, 72 h = 0 in all animals tested) coming from the valid key study.
Eye irritation:
Xi; R41, Cat 1, H318, based on irreversible effects (not fully reversible within 21 d) coming from the valid key study.
Since data used for classified in Annex VI are not known a precautionary classification is propsed as follows:
Skin irritation: Cat 2, H315 and Xi; R38
Eye irritation: Cat 1, H318 Xi; R41
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