Registration Dossier
Registration Dossier
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EC number: 203-481-7 | CAS number: 107-31-3
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions. Restriction: not reported whether treatment-related body weight changes observed.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- ; body weight was not controlled
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Methyl formate
- EC Number:
- 203-481-7
- EC Name:
- Methyl formate
- Cas Number:
- 107-31-3
- Molecular formula:
- C₂H₄O₂
- IUPAC Name:
- methyl formate
- Details on test material:
- - Test substance: Methyl formate
- Analytical purity: 9
- Impurity. methanol 2%.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: males 250 g, females 180 g
Administration / exposure
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: backside, 42 cm²
- % coverage:
- Doses:
- 2000 and 4000 mg/kg bw
- No. of animals per sex per dose:
- 3
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: animals were observed daily for signs of toxicity. Mortalities were recorded.
- Necropsy of survivors performed: yes/no all animals were examined after death or at termination.
- Other examinations performed: clinical signs, body weight,organ weights, histopathology.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 4 000 mL/kg bw
- Mortality:
- No mortality seen at any dose within the 14-d observation period.
- Clinical signs:
- Slight apathy, stagger, unsteady gait, unregular breathing. No signs of local irritation noted.
Applicant's summary and conclusion
- Executive summary:
Conclusion:
There were no deaths (0/12) in rats after dermal contact to methyl formate at the Limit Test concentration and at 4000 mg/kg bw.
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