Sodium phenylacetate

Endpoint summary

Description of key information

Biodegradation in water:

Biodegradbility of test chemical sodium 2-phenylacetate (CAS no. 114 -70 -5) is predicted using OECD QSAR tool box v.3.3 using log Kow as primary descriptor. The test chemical sodium 2-phenylacetate showed 1 % biodegradation by considering BOD as a parameter and microorganism as a inoculumin 28 days. By this value of percent biodegradability this chemical sodium 2- phenylacetate is considered as not readily biodegradable.

Biodegradation in water and sediment:

Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound sodium 2-phenylacetate (CAS No: 114 -70 -5) .If released in to the environment, 26.6 % of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of the chemical sodium 2-phenylacetate in water is estimated to be 15 days (360 hrs). The half-life (15 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is low whereas the half-life period of sodium 2-phenylacetate in sediment is estimated to be 135 days (3240 hrs).  However, as the percentage release of test chemical into the sediment is less than 1 % (i.e, reported as 0.0816 %), indicates that test chemical sodium 2-phenylacetate is not persistent in sediment.

Biodegradation in soil:

The half-life period of sodium 2-phenylacetate(CAS No: 114 -70 --5) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 72.2 % of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical sodium 2-phenylacetate in soil is estimated to be 30 days (720 hrs). Based on this half-life value of test chemical sodium 2-phenylacetate, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.

Additional information

Biodegradation in water:

Predicted data for target compound sodium 2-phenylacetate (CAS no. 114 -70 -5) and supporting weight of evidence studies for its closest read across chemicals with log Kow as a primary descriptor were reviewed for the biodegradation endpoint which are summarized as below.

Biodegradability of test chemical sodium 2-phenylacetate (CAS no. 114 -70 -5) is predicted using OECD QSAR tool box v.3.3 using log Kow as primary descriptor. The test chemical sodium 2-phenylacetate showed 1 % biodegradation by considering BOD as a parameter and microorganism as a inoculums in 28 days. By this value of percent biodegradability this chemical sodium 2- phenylacetate is considered as not readily biodegradable.

 

In the Supporting weight of evidence study from authoritative database (J Check, 2017) of read across chemical Sodium 2-(naphthalen-1-yl) acetic acid (CAS no. 86-87-3) biodegradation test was carried out by taking sludge as inoculums at 30 mg/L concentration. Biodegradation was analyzed by BOD, TOC and HPLC parameter. The initial concentration of read across chemical was 100 mg/L and study design is of standard type. After 2 weeks (14 days) test chemical 2-(naphthalen-1-yl) acetic acid showed 0% biodegradation BOD parameter, 5 % biodegradation by TOC parameter and 1 % biodegradation by HPLC parameter in 14 days. So it is concluded that this read across chemical is not readily biodegradable.

 

In another supporting weight of evidence study from same source as mentioned above of read across chemical Benzylbenzene (CAS no. 101-81-5) biodegradation test was carried out by taking sludge as inoculums at 30 mg/L concentration. Biodegradation was analysed by using BOD and GC parameters. The initial concentration of read cross chemical was 100 mg/L and study design is of improved type for a volatile substance. After 2 weeks (14 days) read across chemical showed 0% biodegradation by both BOD and GC parameter so it is concluded that this read across chemical is not readily biodegradable

 

On the basis of above results for target chemical sodium 2-phenylacetate (CAS no. 114 -70 -5) from (OECD QSAR tool box v3.3 2017) and for its read across substances (from authoritative database J Check) the target chemical sodium 2-phenylacetate can be expected to be not readily biodegradable.

Biodegradation in water and sediment:

Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound sodium 2-phenylacetate (CAS No:114-70-5). If released in to the environment, 26.6 % of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of the chemical sodium 2-phenylacetate in water is estimated to be 15 days (360 hrs). The half-life (15 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is low whereas the half-life period of sodium 2-phenylacetate in sediment is estimated to be 135 days (3240 hrs).  However, as the percentage release of test chemical into the sediment is less than 1 % (i.e, reported as 0.0816 %), indicates that test chemical sodium 2-phenylacetate is not persistent in sediment.

Biodegradation in soil:

The half-life period ofsodium 2-phenylacetate (CAS No: 114 -70 -5) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 72.2 % of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemicalsodium 2-phenylacetate in soil is estimated to be 30 days (720 hrs). Based on this half-life value of test chemicalsodium 2-phenylacetate, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.