Registration Dossier
Registration Dossier
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EC number: 203-233-8 | CAS number: 104-75-6
Endpoint summary
Administrative data
Description of key information
The test substance is considered to be corrosive to rabbits' skin and eye under the test conditions chosen.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation:
Skin irritation was analyzed according to OECD 404. After 3 min of exposure 2-ethylhexylamine produced dermal corrosion at all sites. The dermal response was initially characterized by necrosis at three minutes and progressed to eschar (scab) at 24 hours post-dose. The eschar persisted through the remainder of the seven-day study. During the test period, a very slight to moderate edema, which diminished by the end the study, was noted (Hoechst AG 1988, reliability score: 1). In a primary skin irritation study with undiluted 2-ethylhexylamine exposure times of 1, 5 and 15 min caused irreversible leather-like necrosis or hard necrosis, both defined by complete destruction of the skin tissue involving all individual layers of the skin (BASF AG 1968; reliability score 2). In 24 h vesicant test the undiluted compound produced necrosis on 4 of 5 rabbits and the 4 h rabbit belly irritation test also indicated the production of necroses of the skin (Smyth et al. 1949; reliability score: 2).
Eye irritation:
In a primary eye irritation study in rabbits, 50 µL of the test substance were applied to the conjunctival sac of one eye in 2 animals and caused irreversible corrosive effects. After 8 days severe chemical burnings of eyelids and eye ball, iritis, crust formation on eye lids, secretion of pus, loss of bulbus was observed (BASF AG 1968; reliability score 2). A publication confirmed these severe corrosive effects (Smyth et al. 1949; reliability score: 2).
Justification for classification or non-classification
Classification, Labeling, and Packaging Regulation (EC) No. 1272/2008
The available experimental test data are reliable and suitable for classification purposes under Regulation 1272/2008. The substance is considered to be classified as skin corrosive cat. 1A (H314) and as causing severe eye damage cat. 1 (H318) under Regulation (EC) No 1272/2008, as amended for the tenth time in Regulation (EC) No 2017/776.
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