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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP study according to OECD / EU guidelines

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2006

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
GLP compliance:
yes (incl. certificate)
Test type:
acute toxic class method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
female

Administration / exposure

Route of administration:
oral: gavage

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
> 300 - < 2 000 mg/kg bw

Any other information on results incl. tables

The results indicate that 3,4’-Dichlordiphenylether has a toxic effect in the rat following single oral administration at a dose level of 2000 mg/kg, while a dose level of 300 mg/kg is well tolerated. The mortality pattern demonstrates the acute oral LD50 to be less than 2000 mg/kg, but greater than 300 mg/kg body weight.

Applicant's summary and conclusion

Conclusions:
In a study according to OECD Guideline No. 423 the LD50 of 3,4’-Dichlordiphenylether was determined to be less than 2000 mg/kg, but greater than 300 mg/kg body weight.