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EC number: 280-349-5 | CAS number: 83261-15-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
skin
rabbit, 4 h, occlusive: mildly irritant (OECD 404, BASF 1983)
eye
rabbit, eyes not rinsed: not irritant (OECD 405; BASF 1983)
Key value for chemical safety assessment
Additional information
There are reliable data from animal studies available to assess the skin and eye irritation potential of the test substance.
skin
In a study following the former version of the OECD guideline 404 using occlusive conditions, shaved skin areas of three Vienna White rabbits received ca. 0.5 mL of the unchanged test substance (purity unknown). The skin areas were treated for 4 hours under occlusive conditions before washing. The individual erythema score were 1.0, 1.7 and 2.0 during the relevant reading period (24 -72 h) and the corresponding edema scores were 0.0, 0.0 and 0.7 (scores according to the OECD/Draize scheme). Erythema and edema were completely reversible within 8 days and 48 hours, respectively. Desquamation was observed in all three animals at the final reading after 8 days. Under the conditions of the test, the test substance fulfilled the criteria as "mildly irritant to the skin" following GHS requirements (BASF 1983).
eye
In a study according to OECD guideline 405, 100 µL of the unchanged test substance (purity unknown) was instilled into the conjunctival sac of the right eyes of three Vienna White rabbits; the eyes were not rinsed. The eyes were scored at 1 h, 24 h, 48 h, 72 h, and 8 d after instillation. Findings were evaluated according to the OECD/Draize scheme. The untreated left eye of each rabbit served as control. No effects were seen at the cornea and iris. Redness (up to score 2, “well defined”) of the conjunctivae, swelling of the conjunctivae and secretion was noted. The individual scores during the relevant reading period (24-72 h) were 0.3, 1.3 and 1.7 for conjunctivae redness, 0.0, 0.3 and 0.3 for swelling of the conjunctivae and three times 0.3 for secretion, respectively. All eyes were normal by day 8 (BASF 1983).
Justification for classification or non-classification
Following the available test result, the test substance has not to be classified as skin irriating according to 67/548/EEC, but as mild skin irritant (Cat. 3) according to GHS requirements.
According to the available test result, the test substance has not to be classified as irriating to the eye according to 67/548/EEC and GHS requirements, respectively.
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