Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-757-1 | CAS number: 87-61-6
Carcinogenicity
Administrative data
- Endpoint:
- carcinogenicity
- Remarks:
- intraperitoneal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
Data source
Reference
- Title:
- No information
- Author:
- Herren-Freund, S.L., Pereira, M.A. (1986): Environ. Health|Perspect. 69, 59 - 65
Materials and methods
- Principles of method if other than guideline:
- 1,2,3- Trichlorobenzene was tested for initiating and/or promoting activity in rat liver by using rat liver foci bioassay (see freetext)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,2,3-trichlorobenzene
- EC Number:
- 201-757-1
- EC Name:
- 1,2,3-trichlorobenzene
- Cas Number:
- 87-61-6
- Molecular formula:
- C6H3Cl3
- IUPAC Name:
- 1,2,3-trichlorobenzene
- Details on test material:
- IUCLID4 Test substance: other TS: 1,2,3-trichlorobenzene purity: no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Duration of treatment / exposure:
- see Method
- Frequency of treatment:
- see Method
Doses / concentrations
- Remarks:
- Doses / Concentrations:
1mmol/kg bw (181.6 mg/kg bw)
Basis:
- Control animals:
- other: yes, positive control: phenobarbital
- Details on study design:
- Post-exposure period: see Method
Results and discussion
Any other information on results incl. tables
RS-Freetext:
1.2.3-trichlorobenzene does not promote the DENA-initiated
GGT foci either in male or female rats.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
