Registration Dossier
Registration Dossier
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EC number: 208-336-1 | CAS number: 522-75-8
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from peer reviewed journals
Data source
Reference
- Reference Type:
- publication
- Title:
- Contribution to the Pharmacology of the Benzothiazoles
- Author:
- MARSTON TAYLOR BOGERT and HELEN G. HUSTED
- Year:
- 1 932
- Bibliographic source:
- Journal of Pharmacology and Experimental Therapeutics, June 1932, 45 (2) 189-207
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To assess the ocular irritation potential of the test chemical in rabbits
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Benzothiazol-2-ylamine
- EC Number:
- 205-268-4
- EC Name:
- Benzothiazol-2-ylamine
- Cas Number:
- 136-95-8
- Molecular formula:
- C7H6N2S
- IUPAC Name:
- 1,3-benzothiazol-2-amine
- Test material form:
- solid
- Details on test material:
- Name of the test chemical:1,3-benzothiazol-2-amine
Common Name: 2-aminobenzothiazole
Molecular Formula:C7H6N2S
Molecular Weigth: 150.2044 g/mol
Substance Type: Organic
InChI: 1S/C7H6N2S/c8-7-9-5-3-1-2-4-6(5)10-7/h1-4H,(H2,8,9)
Physical State: Solid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- no data available
Test system
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- undiluted test chemical
- Duration of treatment / exposure:
- Single exposure
- Observation period (in vivo):
- no data available
- Duration of post- treatment incubation (in vitro):
- no data available
- Number of animals or in vitro replicates:
- no data available
- Details on study design:
- TEST SITE
- Area of exposure: conjunctival sac
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: no data available
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No irritation observed
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- There was neither local nor central action when the test chemical was applied to the conjunctival sac of rabbits.
Hence, the test chemical can be considered not irritating to rabbit eyes. - Executive summary:
The ocular irritation potential of the test chemical was assessed in rabbits.
The test chemical was applied to the conjunctival sac of rabbits and observed for signs of irritation (dose and duration not mentioned).
There was neither local nor central action when the test chemical was applied to the conjunctival sac of rabbits.
Hence, the test chemical can be considered not irritating to rabbit eyes.
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