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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
publication
Title:
The comparative acute toxicity and primary irritancy of the monohexyl ethers of ethylene and diethylene glycol.
Author:
Ballantyne, B. & Myers, R.C.
Year:
1987
Bibliographic source:
Vet. Hum. Toxicol. 29, 361-366

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
no
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female
Details on test animals and environmental conditions:
As described in guideline.

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Duration of exposure:
24 h
Doses:
males: 0.9, 1.9, 3.7 g/kg bw
females: 0.9, 1.9, 2.6, 3.7 g/kg bw
No. of animals per sex per dose:
5
Control animals:
not required

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LD50
Effect level:
2 000 mg/kg bw
Sex:
female
Dose descriptor:
LD50
Effect level:
2 216 mg/kg bw
Mortality:
Mortalities occurred at a dose level of 1.9 g/kg bw and above.
Clinical signs:
Signs of toxicity included salivation, sluggishness, unsteady gait and comatose appearance.
Body weight:
Body weight decreased during the first post-application week and recovered during the second week with the 1.9 mg/kg bw females.
Gross pathology:
Animals that died showed dark red or dark pink lungs.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met