N,N,N-trimethylanilinium chloride

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

data is from authoritative databases

Data source

Reference

Reference Type:

other: Authoritative database

Title:

GESTIS for the CAS: 138-24-9

Author:

Institut für Arbeitsschutz der Deutschen Gesetzlichen Unfallversicherung (IFA)

Year:

2016

Bibliographic source:

Institut für Arbeitsschutz der Deutschen Gesetzlichen Unfallversicherung (IFA), 2016

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

Eye irritation test of chemical Trimethylanilinium chloride was conducted in rabbits

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

N,N,N-trimethylanilinium chloride

EC Number:

205-319-0

EC Name:

N,N,N-trimethylanilinium chloride

Cas Number:

138-24-9

Molecular formula:

C9H14N.Cl

IUPAC Name:

N,N,N-trimethylanilinium chloride

Test material form:

solid: crystalline

Details on test material:

- Name of test material (as cited in study report): N,N,N-trimethylanilinium chloride
- Molecular formula : C9H14N.Cl
- Molecular weight : 171.67 g/mol
- Smiles notation: [Cl-].C[N+](C)(C)c1ccccc1
- InChl : InChI=1/C9H14N.ClH/c1-10(2,3)9-7-5-4-6-8-9;/h4-8H,1-3H3;1H/q+1;/p-1
- Substance type: Organic
- Physical state: Solid

Specific details on test material used for the study:

- Name of test material (as cited in study report): N,N,N-trimethylanilinium chloride
- Molecular formula: C9H14N.Cl
- Molecular weight: 171.67 g/mol
- Smiles notation: [Cl-].C[N+](C)(C)c1ccccc1
- InChl : InChI=1/C9H14N.ClH/c1-10(2,3)9-7-5-4-6-8-9;/h4-8H,1-3H3;1H/q+1;/p-1
- Substance type: Organic
- Physical state: Solid

Test animals / tissue source

Species:

rabbit

Strain:

not specified

Test system

Vehicle:

unchanged (no vehicle)

Controls:

not specified

Amount / concentration applied:

30 mg powdered

Duration of treatment / exposure:

No data available

Observation period (in vivo):

No data available

Number of animals or in vitro replicates:

3 animals

Details on study design:

Area of exposure: conjunctival sac

Results and discussion

In vivo

Results

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

other: no data available

Reversibility:

not specified

Remarks on result:

no indication of irritation

Irritant / corrosive response data:

No significant irritation was seen in a test on rabbits eyes in which 30 mg of powdered chemical was instilled into the conjunctival sac but one of 3 animals died.

Applicant's summary and conclusion

Interpretation of results:

other: not irritating

Conclusions:

No significant irritation was noted but one of 3 animals died. Hence,the test chemical was considered to be non irritating to the conjunctival sac of rabbits.

Executive summary:

Eye irritation test was performed on rabbits to evaluate the irritation potential of the test chemical The test chemical was instilled into the conjunctival sac of rabbits. 30 mg of powdered test chemical was installed into the conjunctival sac of 3 rabbits (observation period, duration of exposure not mentioned).

No significant irritation was noted but one of 3 animals died. Hence,the test chemical was considered to be non irritating to the conjunctival sac of rabbits.