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EC number: 931-295-2
CAS number: -
Skin irritation scores:
* Examinations were performed at the
specified times after removal of the dressing.
n.a. = not assessable due to necrosis
produced by the test item.
† = no observation point (animal was killed
on test day 2)
Skin Irritation Scores - Mean Values
after 24, 48 and 72 Hours
Not applicable. Since one animal was killed
after the 24-hour observation point (female) and one
animal after the 48-hour observation point
(male), mean scores could not be assessed.
Skin Irritation Scores - Assessment
According to EC Classification Guidelines
3 min (91, M)
1h, 24h, 48h
4 hours (92, F)
Body weights (g):
skin irritation potential of Alkoxypropandiamineacetate and
alkoxypropandiamine was investigated according to OECD test guideline
No. 404 and Commission Regulation (EC) No. 440/2008, B.4. The test item
was applied by topical semi-occlusive application of 0.5 mL to the
intact left flank of two adult New Zealand White rabbits. The duration
of treatment was four hours (for one female, by mistake) or three
minutes (for one male). The scoring of skin reactions was performed 1
and 24 hours (female) or 1, 24 and 48 hours after removal of the
score could not be calculated across 3 relevant scoring times (24, 48
and 72 hours after patch removal, according to the guidelines) since the
animals were killed due to ethical reasons either on test day 2 (female)
or 3 (male).
application of Alkoxypropandiamineacetate and alkoxypropandiamine to the
skin resulted in severe erythema and oedema and depigmentation of the
treated skin (blanching) one hour after the 4-hour application period
(female). At the 24-hour observation point, the entire treated skin area
was necrotic and the animal was killed for ethical reasons. Then, the
application period was shortened to 3 minutes (male). Well-defined
erythema, slight oedema and blanching were noted one hour after removal
of the dressing. However, at the 24-hour observation point, the treated
skin area evolved a necrosis, which persisted until the 48-hour
observation point when this animal was also killed for ethical reasons.
For both animals teated, no clinical signs were recorded throughout the
test item induced irreversible damage to the skin.
upon the referred classification criteria (Regulation (EC) No 1272/2008
of the European Parliament and of the Council of 16 December 2008),
Alkoxypropandiamineacetate and alkoxypropandiamine is classified in
Category 1: “Corrosive” and further in Subcategory 1B.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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