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EC number: 931-295-2
CAS number: -
One non-GLP OECD 225 sediment study has been performed on the substance. This test was done to compare sediment toxicity with diamine HT. The results indicates that the etherdiamine is less toxic to sediment compared to diamine HT. Hence, the read across is supported. Three long term studies are performed on Diamine HT, and the most reliable Lumbriculus study was used as a key valus for the chemical risk assessment.
One study was conducted to support read across for the sediment toxicity
using the REACH registered Diamine HT ( Amines, N-C16-18-alkyl
(evennumbered) propane-1,3-diamine, EC number 696-364-9) as a source
with Etherdiamine (1,3-Propanediamine, N-[3-((C11-14,
C13-rich)oxy)propyl]- branched acetate, EC number 931-295-2) as a target.
The performed study showed that the source for the read across (diamine
HT), is more toxic to sediment organisms then the target, etherdiamine.
Hence, using sediment data from diamine HT for risk assessment of
ehterdiamine is by the registrans considered as a worst case, based on
the reported NOECs of the two substance (68 mg/kg dw for the source,
diamine HT and 134 mg/L dw for the target, etherdiamine).
For the group of diamines, four test
results are available regarding the sediment toxicity. However, for this
read across, only the three studies performed on Diamine HT was used. The
PNEC for the etherdiamine, is derived exactly as the PNEC for the source (diamine
The long term studies were performed
with the hydrogenated diamine C16 -18 and were performed withLumbriculus
variegatusandCaenorhabditis elegans.The long-term study withCaenorhabditis
elegansshowed no effects upto 1000 mg/kg dw. Two long-term tests withLumbriculus
variegatuswere performed applying two different spiking approaches.
In the first test a solvent was used to spike the test substance on the
sand fraction and in the second test the test substance was spiked onto
the whole sediment in the water phase at a slightly elevated
temperature. In the first test with solvent spiking, a significant
difference in reproduction between the normal control and solvent
control was observed. It was not clear why this difference was observed
but considering to unrealism in using a solvent to spike the test
substance it was decided to repeat the test using an environmentally
more realistic solvent free spiking procedure of the whole sediment. For
this second long-termLumbriculus variegatusa NOEC and EC10 for
reproduction was observed of resp. 180 mg/kg dw and 86 mg/kg dw. The
NOEC and EC10 based on dry weight of resp 360 and 237 mg/kg dw are
higher probably because the moment of splitting of the worms is slightly
influenced by the test substance.
The spiking procedure using a solvent to
spike the sand fraction is unrealistic for cationic surfactants.
Cationic surfactants which may enter surface water are normally sorbed
to dissolved organic matter or suspended matter and may redistribute
slowly to thermodynamically more favourable sites when available. Quartz
sand has a very low CEC and no organic matter. The use of natural
sediment spiked without using solvent is far more realistic and could
allow a more evenly distribution of the test substance over the
sediment. In addition it would allow the ingestion of the test substance
more realistically. In addition the solvent apparently had a positive
influence on the reproduction which limits the reliability of the
Overall, the EC10 from the most reliable Lumbriculs study was used as
key value for the chemical safety assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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