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EC number: 931-295-2
CAS number: -
reaction mass of etherdiamine and etherdiamine acetate have a strong
tendency to adsorb to negatively charged surfaces such as suspended
matter, algae and test vessels or organic material (including dissolved
organic matter such as humic acids). Many cationic substances in general
rank among the most difficult substances to test in environmental
toxicology. Standard guideline studies are inappropriate to test
substances with such properties and the current REACH Guidance Documents
do not provide sufficient guidance concerning bioavailability and
exposure assessment for cationic surface-active substances like the etherdiamines
as these were written with normal hydrophobic chemicals in mind, failing
to take into account the lack of bioavailability that occurs in the
environment with these substances.
long-term aquatic ecotoxicity tests with the reaction mass of etherdiamine
and etherdiamine acetate were therefore performed in river water to
allow a PECaquatic,bulk/PNECaquatic,bulkapproach
and is considered to be conservative but more environmentally realistic
than the standard method. This approach is based on PEC estimations
representing ‘total aquatic concentrations’. To characterize the risk to
the aquatic compartment the PECaquatic,bulkis compared with
the PNECaquatic,bulkderived from river water ecotoxicity
studies (ECETOC, 2001).
order to classstandardlaboratory toxicity study valid, it is of
particular importance that - besides information on test substance, test
method / conditions and test organism used - suitable precautions are
taken to prevent the loss of test substance by adsorption and that
exposure concentrations are based upon measured levels.
ecotoxicity tests performed using thebulkapproach, however,
adsorption to suspended matter and DOC is acceptable and only adsorption
to glassware should be accounted for. For a valid bulk approach test the
concentration-effect relationship should be based on the sum of adsorbed
and dissolved substance in the volume of the medium tested. One of the
advantages of the bulk approach tests with these difficult substances is
that in the presence of suspended matter, humic acids and/or algae, the
residual sorption to glassware will be negligible. The results of these
bulk approach tests are therefore much easier to interpret, more
environmental realistic, and if compared to PECbulkclearly
provide a more appropriate assessment of risks for the environment. All
effect values given are therefore based on the nominal test item
PNECaquatic bulkshould be calculated using the assessment
factor proposed by the TGD. As long-term NOECs from species representing
two trophic levels are available (algae and daphnia) an assessment
factor of 50 may be used.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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