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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Basic toxicokinetics

Currently viewing:

Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from EFSA journal and IARC monograph.

Data source

Reference
Reference Type:
publication
Title:
Opinion of the Scientific Panel on Food Additives,Flavourings,Processing Aids and Materials in Contact with Food on a request from the Commission to Review the toxicology of number of dyes illegally present in food in the EU Question number EFSA-2005-082
Author:
European Food Safety Authority
Year:
2005
Bibliographic source:
The EFSA Journal (2005) 263, 1-71

Materials and methods

Objective of study:
excretion
metabolism
Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Metabolism and excretion of the target substance 1-[(2,4-dimethylphenyl)diazenyl]-2-naphthol was studied in rats.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
1-(2,4-dimethylphenylazo)-2-naphthol
EC Number:
221-490-4
EC Name:
1-(2,4-dimethylphenylazo)-2-naphthol
Cas Number:
3118-97-6
Molecular formula:
C18H16N2O
IUPAC Name:
1-(2,4-dimethylphenylazo)-2-naphthol
Test material form:
solid: crystalline
Details on test material:
- Name of test material : C.I. Solvent Orange 7
- Molecular formula : C18H16NO
- Molecular weight : 276.3374 g/mol
- Smiles notation : Cc1ccc(N=Nc2c(O)ccc3ccccc23)c(C)c1
- InChl : 1S/C18H16N2O/c1-12-7-9-16(13(2)11-12)19-20-18-15-6-4-3-5-14(15)8-10-17(18)21/h3-11,21H,1-2H3/b20-19+
- Substance type:Organic
- Physical appearance : Solid
Radiolabelling:
not specified

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
corn oil
Details on exposure:
no data
Duration and frequency of treatment / exposure:
no data
Doses / concentrations
Remarks:
not specified
No. of animals per sex per dose / concentration:
no data
Control animals:
not specified
Positive control reference chemical:
no data
Details on study design:
no data
Details on dosing and sampling:
no data
Statistics:
no data

Results and discussion

Main ADME resultsopen allclose all
Type:
metabolism
Results:
Th dye was easily reduced by intestinal bacteria to 1-amino-2naphthyl sulphate and eight 8 other metabolites, five of whch were red-coloured
Type:
excretion
Results:
excreted in urine

Metabolite characterisation studies

Metabolites identified:
yes
Details on metabolites:
1-amino-2naphthyl sulphate and 8 other metabolites (name not specified)

Applicant's summary and conclusion

Conclusions:
The dye 1-[(2,4-dimethylphenyl)diazenyl]-2-naphthol is said to be easily reduced by intestinal bacteria, after gavage administration to rats in corn oil 1-amino-2naphthyl sulphate and 8 other metabolites were excreted in urine.
Executive summary:

The dye 1-[(2,4-dimethylphenyl)diazenyl]-2-naphthol is said to be easily reduced by intestinal bacteria, after gavage administration to rats in corn oil 1-amino-2naphthyl sulphate and 8 other metabolites were excreted in urine.