Registration Dossier
Registration Dossier
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EC number: 610-619-3 | CAS number: 51145-61-0
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 471 and 472
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.13/14 (Mutagenicity - Reverse Mutation Test Using Bacteria)
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 2,3,4,9-tetrahydro-1H-carbazol-3-one
- EC Number:
- 610-619-3
- Cas Number:
- 51145-61-0
- Molecular formula:
- C12H11NO
- IUPAC Name:
- 2,3,4,9-tetrahydro-1H-carbazol-3-one
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- other: TA 98, TA 100, TA 1535, TA 1537, Escherichia coli, CM891
- Metabolic activation:
- with and without
- Metabolic activation system:
- Aroclor 1254 rat liver S9-Mix
- Test concentrations with justification for top dose:
- Concentration range Main test with metabolic activation : 5 - 5000 µg/plate
Concentration range Main test without metabolic activation : 5 - 5000 µg/plate
Controls
- Untreated negative controls:
- yes
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- yes
- Positive controls:
- yes
- Positive control substance:
- 9-aminoacridine
- sodium azide
- mitomycin C
- other: Ampicillin, 2-Aminofluorene, N-Ethyl-N'-Nitrosoguanidine (ENNG)
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative with metabolic activation TA 98, TA 100, TA 1535, TA 1537, Escherichia coli, CM891
negative without metabolic activation TA 98, TA 100, TA 1535, TA 1537, Escherichia coli, CM891
It was concluded that the TS did not exhibit any mutagenic activity under the conditions of test.
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