N,N''-(methylenedi-4,1-phenylene)bis[N'-octyl]urea

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

December 10, 2002 - February 7, 2003

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The LOD should have been determined from the noise level of a standard solution. In addition, it is reported that dispersions were used, which implies the presence of undissolved material.

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Version / remarks:

(1992)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

column elution method

Remarks:

(with recirculating pump)

Remarks on result:

other: Inconclusive

Details on results:

- Preliminary test: < 26.3 µg/L

Solution	Mean peak height
Standard 3.76 mg/L	4.693
Standard 5.56 mg/L	5.263
Sample 1A	<LOD*
Sample 1B	<LOD*
Sample 2A	<LOD*
Sample 2B	<LOD*
Standard 4.56 mg/L	5.395
Standard 4.48 mg/L	6.189
Sample 3A	<LOD*
Sample 3B	<LOD*
Sample 4A	<LOD*
Sample 4B	<LOD*
Standard 4.56 mg/L	7.101
Standard 5.28 mg/L	6.567
Sample 5A	<LOD*
Sample 5B	<LOD*
Sample 6A	<LOD*
Sample 6B	<LOD*
Standard 5.04 mg/L	6.223
Standard 5.00 mg/L	5.899
Sample 7A	<LOD*
Sample 7B	<LOD*
Sample 8A	<LOD*
Sample 8B	<LOD*

*LOD: taken as largest integratable peak at approx. 4.7 minutes from Sample 3A, peak height = 4.808 x 10^-3

Sample number	Sampling Time (hour)	Concentration (µ/L)		Solution pH
		Determination: A	Determination: B	Determination: A	Determination: B
1	90	< 4.38	< 4.38	6.9	6.8
2	95	< 4.38	< 4.38	6.9	6.9
3	114	< 4.38	< 4.38	6.8	7.0
4	118	< 4.38	< 4.38	7.0	7.0
5	138	< 4.38	< 4.38	6.7	6.9
6	143	< 4.38	< 4.38	6.8	6.8
7	161	< 4.38	< 4.38	6.9	7.0
8	166	< 4.38	< 4.38	7.0	7.1

Validation

The linearity of the detector response in respect to concentration was assessed over the nominal concentration range of 0 to 10 mg/L. This was satisfactory with a correlation coefficient of 1.000 being obtained (not further reported)

Conclusions:

Interpretation of results (migrated information): insoluble (< 0.1 mg/L)
The substance is insoluble in water. The Competent Authority of France concluded in 2003 that the water solubility of the substance is 4.38 µg/L at 20°C, the LOD determined in the water solubility study.

Description of key information

The water solubility of the substance is 4.38 µg/L at 20°C

Key value for chemical safety assessment

Water solubility:

4.38 µg/L

at the temperature of:

20 °C

Additional information

The Competent Authority of France concluded in 2003 that the water solubility of the substance is 4.38 µg/L at 20°C, the LOD determined in the water solubility study.