Registration Dossier

Administrative data

Description of key information

acute oral toxicity (rat): LD50 > 2000 mg/kg bw
acute dermal toxicity (rat): LD50 > 2000 mg/kg bw

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
discriminating dose
Value:
2 000 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
discriminating dose
Value:
2 000 mg/kg bw

Additional information

No data on acute toxicity are available for the substance dihexyl ether. Acute toxicity studies of the structurally related dioctyl ether show no mortality nor clinical signs in rats for both the oral and dermal route. Based on the similar structure for dihexyl ether also no acute toxicity is expected at these concentrations.

Inhalation toxicity has not been evaluated as the predominant exposure route is via the dermal route.

Justification for classification or non-classification

Based on data on the structurally-related substance dioctyl ether the substance does not need to be classified according to GHS (Regulation (EU) 1272/2008) and also does not need to be classified according to DPD (67/548/EEC).