Registration Dossier
Registration Dossier
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EC number: 203-987-8 | CAS number: 112-58-3
PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
The PBT Assessment for Dihexyl ether (CAS 112 -58 -3) is based on the criteria set out in the “Guidance on information requirements and chemical safety assessment, Chapter R.11: PBT Assessment” (ECHA, 2012d).
Persistence
The substance is readily biodegradable according to a study following OECD guideline 301F (Levertz 2015, 2010; 77% CO2 evolution after 28 d, the 10 -day window was passed). Thus, the test substance does not meet the screening criterion for persistency and it is not considered to be P or vP.
Bioaccumulation
The bioaccumulation potential of Dihexyl ether is expected to be low. The substance is rapidly metabolised and excreted by organisms and thus an accumulation is not expected. This is supported by calculated BCF value of 202 or 1360 using the validated BCFBAF regression based or Arnot-Gobas method, respectively. Thus the substance is not considered to be B or vB.
Toxicity
The experimental chronic aquatic toxicity values for Dihexyl ether are > 0.01 mg/l (ErC10 algae and 21d-EC10 Daphnia). And the acute EC50 values from a standard toxicity test in Daphnia magna and algae are > 0.01 mg/l. The read-across substance Dioctyl ether (CAS 629-82-3), is not classified for specific target organ toxicity, carcinogenicity, mutagenicity or reproductive and developmental toxicity in mammals. The criteria for “T” based on mammalian effects are therefore not met. Thus, the criteria set out in Annex XIII of Regulation (EC) No. 1907/2006 are not met and the substance is considered to be not T.
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