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Classification & Labelling & PBT assessment

PBT assessment

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PBT assessment: overall result

PBT status:
the substance is not PBT / vPvB
Justification:

The PBT Assessment for Dihexyl ether (CAS 112 -58 -3) is based on the criteria set out in the “Guidance on information requirements and chemical safety assessment, Chapter R.11: PBT Assessment” (ECHA, 2012d).

Persistence

The substance is readily biodegradable according to a study following OECD guideline 301F (Levertz 2015, 2010; 77% CO2 evolution after 28 d, the 10 -day window was passed). Thus, the test substance does not meet the screening criterion for persistency and it is not considered to be P or vP.

Bioaccumulation

The bioaccumulation potential of Dihexyl ether is expected to be low. The substance is rapidly metabolised and excreted by organisms and thus an accumulation is not expected. This is supported by calculated BCF value of 202 or 1360 using the validated BCFBAF regression based or Arnot-Gobas method, respectively. Thus the substance is not considered to be B or vB.

Toxicity

No experimental chronic aquatic toxicity data are available fo dihexyl ether, but the acute EC50 value from a standard toxicity test in Daphnia magna is > 0.1 mg/l. The read-across substance Dioctyl ether (CAS 629-82-3), is not classified for specific target organ toxicity, carcinogenicity, mutagenicity or reproductive and developmental toxicity in mammals. The criteria for “T” based on mammalian effects are therefore not met. Thus, the criteria set out in Annex XIII of Regulation (EC) No. 1907/2006 are not met and the substance is considered to be not T.