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EC number: 807-645-4 | CAS number: 701920-77-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according to OECD 402
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- bis[2-(2-butoxyethoxy)ethyl] succinate
- EC Number:
- 807-645-4
- Cas Number:
- 701920-77-6
- Molecular formula:
- C20H38O8
- IUPAC Name:
- bis[2-(2-butoxyethoxy)ethyl] succinate
- Reference substance name:
- bis(2-(2-(butoxyethoxy)ethyl)butanedioate
- IUPAC Name:
- bis(2-(2-(butoxyethoxy)ethyl)butanedioate
- Test material form:
- other: liquid
- Details on test material:
- substance type mono constituent
physical state : clear,colourless,liquid
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Test animals
Charles River ,97633 Sulzfeld , Germany
Age 9-10 weeks male, 12-13 weeks females
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- dorso-lumbar-region
- Duration of exposure:
- 24 hours
- Doses:
- 5000 mg/kg/BW
- No. of animals per sex per dose:
- group of 5 animals males, 5 animals female
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days (or other?) 14 days after dosing.
- Frequency of observations and weighing: Animals were observed soon after dosing and at frequent intervals for the remainder of Day 1 (a period of approximately five hours). On subsequent days animals were observed once in daily until the end of the observation period.
Individual body weight were recorded on Days 1, 8 and 15. Individual weekly bodyweight changes and group mean bodyweight data were calculated.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, other: mortality, dermal respons, macroscopic examination - Statistics:
- no data
Results and discussion
- Preliminary study:
- standard acute method
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no mortality observed
- Clinical signs:
- There were no signs of systemic reaction to treatment.
- Body weight:
- slightly low bodyweight loss were recorded for two female and during the first week, bodyweight trends were comparable for all animals.The decrease was marginal and all animals regained weight in the second week.
- Gross pathology:
- No macroscopic abnormalities were observed for animals killed on day 15.
- Other findings:
- no other findings are observed
Any other information on results incl. tables
Dermal response
Local dermal irritation at the treatment site was assessed daily using the following numerical system:
Erythema/Oedema formation for males and females
No erythema/Oedema: 0
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- The acute lethal dermal dose to rats of BBSA was found to be greater than 5,0 g/kg bodyweight.
- Executive summary:
Acute dermal toxicity was tested in Spraque-Dawley rats at 5.0 g/kg under occlusive dressing. The acute lethal dermal dose to rats of bis(2 -(2 -(butoxyethoxy)ethyl)butanedioate was found to be greater than 5,0 g/kg bodyweight. No macroscopic abnormalities were observed for animals killed on day 15.
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