Registration Dossier
Registration Dossier
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EC number: 262-872-0 | CAS number: 61617-00-3
Endpoint summary
Administrative data
Description of key information
Additional information
Hydrolysis:
In a 5 day preliminary hydrolysis study, ZMB2 showed <10% hydrolysis with an equivalent half life of >1 year at 25 deg C. ZMB2, therefore, is not expected to hydrolyse within the environmental compartment (Harlan Laboratories, 2013).
When considering the results of the investigations carried out to support the read-across from 1,3-dihydro-4(or 5)-methyl-2H-benzimidazole-2-thione (MB2) to 2H-Benzimidazole-2-thione, 1,3-dihydro-4(or 5)-methyl-, zinc salt (2:1) (ZMB2) (LANXESS, 2018), the results of the hydrolysis as a function of pH study conducted with this substance must be reconsidered in light of new information. The overall conclusion in LANXESS (2018) is that ZMB2 exhibits its salt characteristic in aqueous solution, i.e., dissolving in water to MB2 and zinc ions in a matter of seconds. For full details of the investigations conducted relating to hydrolysis, refer to Section 13.2 of IUCLID.
In the HPLC-UV analysis performed in this study, a mobile phase consisting of acetonitrile:water (30:70 v/v) was applied. Under these aqueous conditions, based on the weight of evidence presented in this document, it is clear that ZMB2 will instantly dissociate to MB2 (LANXESS, 2018). Thus in this study it would not have been possible to detect ZMB2 in undissociated form, only MB2 was observable at pHs 4-9.
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