Registration Dossier
Registration Dossier
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EC number: 203-966-3 | CAS number: 112-39-0
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment. Only secondary literature. Original report not available.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 999
- Reference Type:
- publication
- Title:
- Studies on the toxicity of pulp and paper mill effluents—I. Mutagenicity of the sediment samples derived from Kraft paper mills
- Author:
- Kinae N. et al.
- Year:
- 1 979
- Bibliographic source:
- Water Research, Vol. 15, p17, 1979
Materials and methods
- Principles of method if other than guideline:
- Ames test (TA 98, TA 100, TA 1537) and bacillus subtillis assay
- GLP compliance:
- no
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Methyl palmitate
- EC Number:
- 203-966-3
- EC Name:
- Methyl palmitate
- Cas Number:
- 112-39-0
- Molecular formula:
- C17H34O2
- IUPAC Name:
- methyl palmitate
- Details on test material:
- - Name of test material (as cited in study report): methyl palmitate as component of sediment samples collected below a paper mill, compound was isolated and tested
- Analytical purity: not given
Constituent 1
Method
- Target gene:
- his operon
Species / strain
- Species / strain / cell type:
- other: TA 98, TA 100, TA 1537 & Bacillus subtillis
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- not specified
- Test concentrations with justification for top dose:
- 100 µg/plate
Controls
- Untreated negative controls:
- not specified
- Negative solvent / vehicle controls:
- not specified
- True negative controls:
- not specified
- Positive controls:
- not specified
- Positive control substance:
- not specified
Results and discussion
Any other information on results incl. tables
Ames test and Bacillus subtillis assay (rec-effect 10 mg/disk) were found to be negative.
Applicant's summary and conclusion
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