Registration Dossier
Registration Dossier
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EC number: 248-363-6 | CAS number: 27247-96-7
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- other: occupational exposure caused effect observation
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
Data source
Materials and methods
- Study type:
- poisoning incident
- Endpoint addressed:
- basic toxicokinetics
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Effects after occupational exposure
- GLP compliance:
- no
Method
- Type of population:
- occupational
- Subjects:
- 1 operator at a refinery
- Ethical approval:
- not applicable
- Route of exposure:
- inhalation
- Reason of exposure:
- unintentional, occupational
- Exposure assessment:
- not specified
- Details on exposure:
- Exposure to the exhaust of an air powered dosing pump being used to blend 2–Ethylhexyl nitrate into diesel.
Results and discussion
- Clinical signs:
- The operator complained of severe headaches, nausea and giddiness.
- Outcome of incidence:
- Complete recovery within 2–3 hours of exposure ceasing
Applicant's summary and conclusion
- Conclusions:
- 2-ethylhexyl nitrate is absorbed via the inhalation route and causes effects as known from dynamite including headache. Complete recovery within 2–3 hours of exposure ceasing indicates lowering of the internal exposure below effective levels
- Executive summary:
An operator at a refinery was exposed to the exhaust of an air powered dosing pump being used to blend 2–ethylhexyl nitrate into diesel. The operator complained of severe headaches, nausea and giddiness. The operator made a complete recovery within 2–3 hours of exposure ceasing.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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