Registration Dossier
Registration Dossier
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EC number: 269-052-1 | CAS number: 68186-90-3 This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 77310.
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: unsuitable test system for a solid test substance
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
- Reference Type:
- secondary source
- Title:
- C.I. Pigment Brown 24
- Author:
- OECD
- Year:
- 2 002
- Bibliographic source:
- SIDS Initial Assessment Report for SIAM 15
Materials and methods
- Principles of method if other than guideline:
- The inhalation hazard test (IHT; synonymous to IRT, inhalation hazard test) was performed in principle as described in OECD Guideline 403 and in accordance to Smyth et al., Am.Ind.Hyg.Ass.J. 23,95-107 (1962). The aim of the test was to demonstrate the toxicity of an atmosphere saturated with vapors of the volatile components of the test substance at a temperature chosen for vapor generation (i.e. 20 °C for the present test substance).
The animals were exposed to the test substance for 7 hours (flow-through, 200 liters/hour). - GLP compliance:
- no
- Test type:
- other: IHT
Test material
- Reference substance name:
- Chrome antimony titanium buff rutile
- EC Number:
- 269-052-1
- EC Name:
- Chrome antimony titanium buff rutile
- Cas Number:
- 68186-90-3
- Molecular formula:
- (Ti, Sb, Cr) O2
- IUPAC Name:
- manganese(4+) trititanium(4+) pentaantimony(3+) chromium(3+) nickel(2+) octadecaoxidandiide
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: males 190 g/ females 170 g
Administration / exposure
- Route of administration:
- inhalation: vapour
- Analytical verification of test atmosphere concentrations:
- no
- Remarks:
- The nominal concentration was recalculated regarding the air flow and the test substance loss
- Duration of exposure:
- 7 h
- Concentrations:
- 0.1 mg/l
- No. of animals per sex per dose:
- 6
- Control animals:
- no
Results and discussion
Effect levels
- Key result
- Dose descriptor:
- other: IHT
- Remarks on result:
- other: No mortality within 7 hours in a saturated atmosphere.
- Mortality:
- none
- Clinical signs:
- other: nothing abnormal observed
- Gross pathology:
- nothing abnormal observed
Applicant's summary and conclusion
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Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
