Dodecan-1-ol

Water solubility

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Data obtained from a secondary source

Principles of method if other than guideline:

Method: other: (measured)

Water solubility:

4 mg/L

Temp.:

25 °C

Conclusions:

Interpretation of results: slightly soluble (0.1-100 mg/L)
Water solubility value of 4 mg/l was reported for the substance

Reference 2

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2009-09-24

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Test procedure in accordance with national standard methods (ASTM) without GLP.

Qualifier:

according to guideline

Guideline:

other: ASTM E 1148

Deviations:

no

GLP compliance:

no

Type of method:

flask method

Water solubility:

1 mg/L

Temp.:

23 °C

pH:

5.5

Remarks on result:

other: Standard Deviation for these Data : +/- 0.1 mg/L

Measurement

(triple determination)

Results: 1.1 mg/L / 1.0 mg/L / 1.0 mg/L

Mean Concentration in Water: 1.0 mg/L

Standard Deviation for These Data: ±0.1 mg/L

Conclusions:

Interpretation of results: slightly soluble (0.1-100 mg/L)
The water solubility was determined to be 1.0 mg/l at 23 °C.

Executive summary:

Dodecan-1 -ol was determined according ASTM E 1148. The water solubility was determined to be 1.0 mg/l at 23 °C.

Reference 3

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: This result was obtained from a secondary source which is peer-reviewed.

GLP compliance:

not specified

Type of method:

other: slow-stir procedure

Water solubility:

1.93 mg/L

Temp.:

20 °C

Remarks on result:

other: The pH of the solution is not stated, but since the substance is only a very weak acid (pKa ca. 16) it is anticipated to create a neutral solution.

Conclusions:

Interpretation of results: slightly soluble (0.1-100 mg/L)
A water solubility value of 1.93 mg/L was reported in a collection of reliable data which has been subject to peer-review. The result is considered to be reliable.

Reference 4

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Data obtained from a secondary source

Principles of method if other than guideline:

Method: other

GLP compliance:

not specified

Water solubility:

1.7 - 2.9 mg/L

Temp.:

16 °C

Remarks on result:

other: The pH of the solution is not stated, but since the substance is only a very weak acid (pKa > 16) it is anticipated to create a neutral solution.

Water solubility:

2.9 mg/L

Temp.:

34 °C

Remarks on result:

other: The pH of the solution is not stated, but since the substance is only a very weak acid (pKa > 16) it is anticipated to create a neutral solution.

Conclusions:

Interpretation of results: slightly soluble (0.1-100 mg/L)
Water solubility of the substance was obtained from a secondary source

Description of key information

The water solubility of a commercial sample of dodecan-1-ol is 1 mg/L at 23°C and pH 5.5.

Key value for chemical safety assessment

Water solubility:

1 mg/L

at the temperature of:

23 °C

Additional information

The solubility of 1 mg/L at 23°C and pH 5.5 was determined for the substance with the use of a flask method in accordance with ASTM E 1148. The result is considered to be reliable.

It is supported by a value of 1.93 mg/L, taken from a reliable and definitive reference source for solubility data (Letinski, 2002) and consistent results from other reference sources.

 

The value taken from literature for pure alcohol is used in exposure modelling.

 

Discussion of trends in the Category of C6-24 linear and essentially-linear aliphatic alcohols:

As chain length increases, water solubility decreases, because the free energy required for a molecule to dissolve becomes less favourable for larger molecules.