Registration Dossier
Registration Dossier
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EC number: 202-705-0 | CAS number: 98-83-9
Endpoint summary
Administrative data
Description of key information
In older studies with experimental animals it was shown that alpha-methylstyrene may cause slight skin and eye irritation.
For experimental animals there are no data available concerning respiratory irritation. In a limited study Wolf et al. (1956) reported strong eye and nasal irritation in human volunteers exposed to concentrations of >= 600 ppm (see section 7.10.3).
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin irritation:
Monsanto Co. (1972)
species: NZW rabbit
duration: 4 hrs
score: slight erythema and oedema
reversibility: fully reversible within 120 hrs
Union Carbide Co. (1975)
species: rabbit
duration: 24 hrs
score: 3 of 10
reversibility: no data
Monsanto Co. (1972)
species: NZW rabbit
duration: 24 hrs
score: 0 of 8
reversibility: fully reversible within 168 hrs
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Eye irritation:
Monsanto Co. (1972)
species: albino rabbit
duration: 24 hrs
score: 14 of 110 after 1 h
reversibility: fully reversible within 120 hrs
Union Carbide Co. (1975)
species: rabbit
duration: 24 hrs
score: 1 of 10
reversibility: no data
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In a limited study Wolf et al. (1956) reported strong eye and nasal irritation in human volunteers exposed to concentrations of >= 600 ppm. At < 10 ppm odour was not detectable, at 50 ppm was odour was detectable without mucous membrane irritation, 100 ppm were judged as strong tolerable odour and 200 ppm as strong objectionable odour, and >= 600 ppm was judges as very strong odour with strong eye and nasal irritation (see section 7.10.3). These effects occur at concentrations higher than the STEL and the OEL.
Effects on eye irritation: irritating
Effects on respiratory irritation: irritating
Justification for classification or non-classification
Based on the avialable data classifcation as eye and respiratory irritatant (Eye Irrit. 2 & STOT SE 3) is warranted according to EU regulation 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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