Registration Dossier
Registration Dossier
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EC number: 271-030-1 | CAS number: 68514-28-3
Bioaccumulation: aquatic / sediment
Administrative data
- Endpoint:
- bioaccumulation in aquatic species: fish
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance has a low potential for bioaccumulation based on log Kow <=3
Cross-reference
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from October 18, 2007 to November, 5, 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- yes
- Remarks:
- The deviation has no effect on the determination of log Pow of the test substance. See deviation.
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- photometric method
- Type:
- log Pow
- Partition coefficient:
- -2.16
- Temp.:
- 23 °C
- pH:
- 9.1
- Details on results:
- Standard extended uncertainty 0.448.
Deviation:
A stock solution of the test substance should be prepared in n-octanol pre-saturated with water. Because of a low solubility of the test substance in this medium, the stock solution was prepared in water pre-saturated with n-octanol.
This deviation has no effect on the determination of log Pow of the test substance. - Executive summary:
The partition coefficient of the test substance was determined. The shake-flask method was used.
The test was performed according to the Method A.8, Partition coefficient, Directive 92/69/EEC, Published in OJ No L 383A, 1992.
Partition coefficient (log P) of the test substance - Humic acids, potassium salts - determined by shake-flask method is:
log Pow = -2.16 ± 0.45 (pH = 9.1, 23ºC)
The partition coefficient shows some suggestion of concentration dependency.
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
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