Registration Dossier
Registration Dossier
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EC number: 212-782-2 | CAS number: 868-77-9
Specific investigations: other studies
Administrative data
Link to relevant study record(s)
- Endpoint:
- endocrine system modulation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Principles of method if other than guideline:
- The ERE-CALUX bioassay was used to determine the estrogenic activity of the compounds. This is a bioanalytical tool that uses a human breast cancer cell line, which is stably transfected with an ER responsive luciferase reporter gene (VM7Luc4E2). 17β-Estradiol (E2) was used as a reference standard.
- GLP compliance:
- not specified
- Type of method:
- in vitro
- Conclusions:
- HEMA showed no estrogenic activity under the conditions of this assay.
- Endpoint:
- endocrine system modulation
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Screening test.
- Details on study design:
- Type: other: estrogenic activity
Referenceopen allclose all
2-HEMA did not show any estrogenic activity at concentrations between 10E-7 and 10E-3 M.
Description of key information
In severals screening tests 2-HEMA did not show any estrogenic activity at concentrations between 10E-7 and 10E-3 M.
Additional information
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