Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-419-9 | CAS number: 106-65-0
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Algal growth inhibition: 72 hour EC50 - > 100 mg/L; 72 hour NOEC - 100 mg/L
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 100 mg/L
- EC10 or NOEC for freshwater algae:
- 100 mg/L
Additional information
The toxicity of Dimethyl succinate to the unicellular freshwater green alga Pseudokirchneriella subcapitata was determined according to the principles of OECD test guideline No. 201 and Regulation 440/2008 Method C3. Effects on growth rate and yield over a period of 72 hours were assessed at limit concentration of 100 mg/L. Achieved concentrations were verified by GC-MS analysis.
Dimethyl succinate was found not to inhibit growth of the freshwater green alga Pseudokirchneriella subcapitata after 72 hours exposure at 100 mg/L.
In accordance with ECHA guidance on information requirements and chemical safety assessment, Chapter R.7b: Endpoint specific guidance, the ErC50 endpoint is used in DNEL derivation. This is because use of values based on biomass cannot be applied to an analysis of results from a system in exponential growth without logarithmic transformation.
The predicted EC50 growth rate (freshwater) for Green Algae, estimated using the ECOSAR model v2.0, is 254.4 mg/L.
The predicted NOEC (freshwater) for Green Algae, estimated using the ECOSAR model v2.0, is 26.8 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
