Registration Dossier
Registration Dossier
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EC number: 231-853-9 | CAS number: 7761-88-8
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Non-guideline-conform investigations without GLP with several methodical deficiencies: (i) key information on test substance is missing such as purity, stability, particle size; (ii) test methodology is reported with inadequate details: insufficient description on animal treatment/husbandry, laboratory conditions and other experimental procedures, (iii) inadequate analytical verification of actual exposure concentrations, and lack of documentation of particle size distributions.
Data source
Reference
- Reference Type:
- publication
- Title:
- Data on the experimental toxicology of silver and the establishment of the maximum allowable concentration for its compounds in the air of a work area
- Author:
- Smirnov, V.G.
- Year:
- 1 983
- Bibliographic source:
- Gig Tr Prof Zabol. 12, 33-37 (cited in RTECS database)
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Repeated inhalation exposure of rats for 4 month. Further methodological detail insufficiently or not reported.
- GLP compliance:
- no
Test material
- Reference substance name:
- Silver nitrate
- EC Number:
- 231-853-9
- EC Name:
- Silver nitrate
- Cas Number:
- 7761-88-8
- Molecular formula:
- AgNO3
- IUPAC Name:
- Silver nitrate
- Details on test material:
- Not available.
Constituent 1
Test animals
- Species:
- rat
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Not available.
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Details on inhalation exposure:
- Not available.
Results and discussion
Effect levels
- Dose descriptor:
- other: Results not presented for lack of reliability.
- Remarks on result:
- not measured/tested
- Remarks:
- Effect level not specified
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Disregarded study for lack of reliability.
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