Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-083-8 | CAS number: 78-10-4
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Remarks:
- The result is sourced from secondary literature (BiblioLine). The original reference was not available for review and no further information is available.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Toxicology of New Industrial Chemical Substances (Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv). For English translation, see TNICS*.Cited in BiblioLine, nisc.com
- Author:
- Anon
- Year:
- 1 963
- Bibliographic source:
- Izdatel'stvo Meditsina, Moscow USSR No.1- 1961 5:192
Materials and methods
- Principles of method if other than guideline:
- not specified
- GLP compliance:
- no
Test material
- Reference substance name:
- Tetraethyl orthosilicate
- EC Number:
- 201-083-8
- EC Name:
- Tetraethyl orthosilicate
- Cas Number:
- 78-10-4
- Molecular formula:
- C8H20O4Si
- IUPAC Name:
- tetraethyl orthosilicate
Constituent 1
Test animals
- Species:
- other: mouse and rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Details on dermal exposure:
- not specified
- Duration of exposure:
- not specified
- Doses:
- not specified
- No. of animals per sex per dose:
- Not specified
- Control animals:
- other: not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- other: TDLo
- Effect level:
- 100 other: pph
- Clinical signs:
- other:
Any other information on results incl. tables
Toxic Dose Low: 100 pph
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- In pre-OECD guideline / pre-GLP study (reliability score 4), tetraethyl orthosilicate was determined to have an acute dermal TDLo of 100 pph in the mouse and rabbit. This finding is reported in secondary literature (BiblioLine), but the original reference was not available for review and no further information is available.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
