Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-064-4 | CAS number: 77-86-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Identification
- Display Name:
- Trometamol
- EC Number:
- 201-064-4
- EC Name:
- Trometamol
- CAS Number:
- 77-86-1
- Molecular formula:
- C4H11NO3
- IUPAC Name:
- 2-amino-2-(hydroxymethyl)propane-1,3-diol
Type of substance
- Composition:
- mono-constituent substance
- Origin:
- organic
Other names
- Trade names:
- TRIS AMINO
- Tris Base
- Trizma Base
- trometamol_M+N
Total tonnage band
- Total range:
- 1 000 - 10 000 tonnes per annum
REACH
- Registered as:
- FULL
- Submitted:
- Joint Submission
Publication dates
- First published:
- 15-Mar-2013
- Last modified:
- 10-Oct-2019
Chemical safety assessment
- Performed for this substance:
- YES
Compositions open all close all
- Type:
- legal entity composition of the substance
- State Form:
- solid: particulate/powder
Constituent 1
- Reference substance name:
- Trometamol
- EC Number:
- 201-064-4
- EC Name:
- Trometamol
- CAS Number:
- 77-86-1
- Molecular formula:
- C4H11NO3
- IUPAC Name:
- 2-amino-2-(hydroxymethyl)propane-1,3-diol
- Type:
- boundary composition of the substance
- State Form:
- solid: particulate/powder
Constituent 1
- Reference substance name:
- Trometamol
- EC Number:
- 201-064-4
- EC Name:
- Trometamol
- CAS Number:
- 77-86-1
- Molecular formula:
- C4H11NO3
- IUPAC Name:
- 2-amino-2-(hydroxymethyl)propane-1,3-diol
- Type:
- legal entity composition of the substance
- State Form:
- solid: particulate/powder
Constituent 1
- Reference substance name:
- Trometamol
- EC Number:
- 201-064-4
- EC Name:
- Trometamol
- CAS Number:
- 77-86-1
- Molecular formula:
- C4H11NO3
- IUPAC Name:
- 2-amino-2-(hydroxymethyl)propane-1,3-diol
- Type:
- legal entity composition of the substance
Constituent 1
- Reference substance name:
- Trometamol
- EC Number:
- 201-064-4
- EC Name:
- Trometamol
- CAS Number:
- 77-86-1
- Molecular formula:
- C4H11NO3
- IUPAC Name:
- 2-amino-2-(hydroxymethyl)propane-1,3-diol
- Type:
- legal entity composition of the substance
- State Form:
- solid: particulate/powder
Constituent 1
- Reference substance name:
- Trometamol
- EC Number:
- 201-064-4
- EC Name:
- Trometamol
- CAS Number:
- 77-86-1
- Molecular formula:
- C4H11NO3
- IUPAC Name:
- 2-amino-2-(hydroxymethyl)propane-1,3-diol
- Type:
- legal entity composition of the substance
- State Form:
- solid: particulate/powder
Constituent 1
- Reference substance name:
- Trometamol
- EC Number:
- 201-064-4
- EC Name:
- Trometamol
- CAS Number:
- 77-86-1
- Molecular formula:
- C4H11NO3
- IUPAC Name:
- 2-amino-2-(hydroxymethyl)propane-1,3-diol
- Type:
- legal entity composition of the substance
Constituent 1
- Reference substance name:
- Trometamol
- EC Number:
- 201-064-4
- EC Name:
- Trometamol
- CAS Number:
- 77-86-1
- Molecular formula:
- C4H11NO3
- IUPAC Name:
- 2-amino-2-(hydroxymethyl)propane-1,3-diol
- Type:
- legal entity composition of the substance
Constituent 1
- Reference substance name:
- Trometamol
- EC Number:
- 201-064-4
- EC Name:
- Trometamol
- CAS Number:
- 77-86-1
- Molecular formula:
- C4H11NO3
- IUPAC Name:
- 2-amino-2-(hydroxymethyl)propane-1,3-diol
- Type:
- legal entity composition of the substance
- State Form:
- solid: particulate/powder
Constituent 1
- Reference substance name:
- Trometamol
- EC Number:
- 201-064-4
- EC Name:
- Trometamol
- CAS Number:
- 77-86-1
- Molecular formula:
- C4H11NO3
- IUPAC Name:
- 2-amino-2-(hydroxymethyl)propane-1,3-diol
- Type:
- legal entity composition of the substance
- State Form:
- solid: particulate/powder
Constituent 1
- Reference substance name:
- Trometamol
- EC Number:
- 201-064-4
- EC Name:
- Trometamol
- CAS Number:
- 77-86-1
- Molecular formula:
- C4H11NO3
- IUPAC Name:
- 2-amino-2-(hydroxymethyl)propane-1,3-diol
- Type:
- legal entity composition of the substance
- State Form:
- other: Crystalline
Constituent 1
- Reference substance name:
- Trometamol
- EC Number:
- 201-064-4
- EC Name:
- Trometamol
- CAS Number:
- 77-86-1
- Molecular formula:
- C4H11NO3
- IUPAC Name:
- 2-amino-2-(hydroxymethyl)propane-1,3-diol
- Type:
- legal entity composition of the substance
- State Form:
- solid: particulate/powder
Constituent 1
- Reference substance name:
- Trometamol
- EC Number:
- 201-064-4
- EC Name:
- Trometamol
- CAS Number:
- 77-86-1
- Molecular formula:
- C4H11NO3
- IUPAC Name:
- 2-amino-2-(hydroxymethyl)propane-1,3-diol
- Type:
- legal entity composition of the substance
Constituent 1
- Reference substance name:
- Trometamol
- EC Number:
- 201-064-4
- EC Name:
- Trometamol
- CAS Number:
- 77-86-1
- Molecular formula:
- C4H11NO3
- IUPAC Name:
- 2-amino-2-(hydroxymethyl)propane-1,3-diol
- Type:
- legal entity composition of the substance
Constituent 1
- Reference substance name:
- Trometamol
- EC Number:
- 201-064-4
- EC Name:
- Trometamol
- CAS Number:
- 77-86-1
- Molecular formula:
- C4H11NO3
- IUPAC Name:
- 2-amino-2-(hydroxymethyl)propane-1,3-diol
- Type:
- legal entity composition of the substance
- State Form:
- solid: particulate/powder
Constituent 1
- Reference substance name:
- Trometamol
- EC Number:
- 201-064-4
- EC Name:
- Trometamol
- CAS Number:
- 77-86-1
- Molecular formula:
- C4H11NO3
- IUPAC Name:
- 2-amino-2-(hydroxymethyl)propane-1,3-diol
- Type:
- legal entity composition of the substance
- State Form:
- other: crystalline solid
Constituent 1
- Reference substance name:
- Trometamol
- EC Number:
- 201-064-4
- EC Name:
- Trometamol
- CAS Number:
- 77-86-1
- Molecular formula:
- C4H11NO3
- IUPAC Name:
- 2-amino-2-(hydroxymethyl)propane-1,3-diol
- Type:
- legal entity composition of the substance
- State Form:
- solid: bulk
Constituent 1
- Reference substance name:
- Trometamol
- EC Number:
- 201-064-4
- EC Name:
- Trometamol
- CAS Number:
- 77-86-1
- Molecular formula:
- C4H11NO3
- IUPAC Name:
- 2-amino-2-(hydroxymethyl)propane-1,3-diol
- Type:
- boundary composition of the substance
- State Form:
- solid: particulate/powder
Constituent 1
- Reference substance name:
- Trometamol
- EC Number:
- 201-064-4
- EC Name:
- Trometamol
- CAS Number:
- 77-86-1
- Molecular formula:
- C4H11NO3
- IUPAC Name:
- 2-amino-2-(hydroxymethyl)propane-1,3-diol
Registrants /Suppliers of the substance open all close all
Latest dossier received | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Registrant / Supplier details | 2009 | 2010 | 2011 | 2012 | 2013 | 2014 | 2015 | 2016 | 2017 | 2018 | 2019 | |
Abbott Diagnostics GmbH Max Planck Ring 2 D-65205 Delkenheim Germany | X | |||||||||||
Acros Organics bvba Janssen Pharmaceuticalaan 3a B-2440 Geel Belgium | X | |||||||||||
o | ANGUS CHEMIE GMBH Zeppelinstr. 30 Postfach 4003 D-49479 Ibbenbueren-Uffeln Germany | X | ||||||||||
ANGUS CHEMIE OR1 Zeppelinstrasse 30 49479 Ibbenbueren Germany | X | |||||||||||
o | AppliChem GmbH Ottoweg 4 64291 Darmstadt Hessen Germany | X | ||||||||||
Avantor Performance Materials Poland S.A. Sowińskiego 11 44-100 Gliwice Poland | X | |||||||||||
Beckman Coulter France SAS Paris Nord 2 33 Rue des Vanesses 95942 Roissy CDG CEDE France | X | |||||||||||
Beckman Coulter GmbH Europark Fichtenhain B13 47807 Krefeld Germany | X | |||||||||||
Becton Dickinson Distribution Center NV Laagstraat 57 9140 Temse Belgium | X | |||||||||||
Biesterfeld Spezialchemie GmbH Ferdinandstr. 41 20095 Hamburg Germany | X | |||||||||||
CHEMICAL INSPECTION & REGULATION SERVICE LIMITED Regus Harcourt Centre D02 HW77 Dublin Ireland | X | |||||||||||
Clarochem Ireland Ltd damastown mulhuddart dn 15 dublin Ireland | X | |||||||||||
Ercros SA Avenida Diagonal 593-595 08014 Barcelona Spain | X | |||||||||||
F.I.S. Fabbrica Italiana Sintetici S.p.a. Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy | X | |||||||||||
Fisher Scientific UK Ltd Bishop Meadow Rd LE11 5RG Loughborough Leicestershire United Kingdom | X | |||||||||||
HH Compliance The Rubicon Centre, CIT Campus, Bishopstown, Cork Ireland | X | |||||||||||
HH Compliance Ltd Rubicon Centre C.I.T. Campus T12 Y275 Bishopstown Cork Ireland | X | |||||||||||
LABIANA PHARMACEUTICALS S.L. Carrer Casanova, 27-31 08757 Corbera de Llobregat Spain | X | |||||||||||
Life Technologies Europe BV Kwartsweg 2 2665 NN Bleiswijk Netherlands | X | |||||||||||
LusoChimica S.p.A. Via Giotto, 9 23871 Lomagna (Lecco) Italy | X | |||||||||||
MACHEREY-NAGEL GmbH & Co. KG Neumann-Neander-Str. 6-8 52355 Dueren NRW Germany | X | |||||||||||
Merck KGaA Frankfurter Strasse 64293 Darmstadt Germany | X | |||||||||||
Merck S.L.U. Calle Maria de Molina 28006 Madrid Spain | X | |||||||||||
Oxoid Limited Wade Road RG24 8PW Basingstoke Hampshire United Kingdom | X | |||||||||||
QUIMICA SINTETICA, S.A. C/ Dulcinea, s/n 28805 Alcalá de Henares Madrid Spain | X | |||||||||||
RADIANT COLOR europark 1046 3530 HOUTHALEN Belgium | X | |||||||||||
Roche Diagnostics GmbH Sandhoferstrasse 116 68305 Mannheim Germany | X | |||||||||||
Siemens Healthcare Diagnostics Products GmbH Emil-von-Behring-Str. 76 35041 Marburg Germany | X | |||||||||||
Siemsgluss Ibérica, S.A. Pol. Ind. Sant Antoni, parcela 6, nave 2 08620 Sant Vicenç dels Horts Barcelona Spain | X | |||||||||||
SIGMA-ALDRICH CHEMIE GMBH Riedstrasse 2 89555 Steinheim Germany | X | |||||||||||
SIGMA-ALDRICH CHIMIE SARL 80 Rue de Luzais BP 701 38297 Saint Quentin Fallavier France | X | |||||||||||
Sigma-Aldrich Company Limited The Old Brickyard, New Road SP8 4XT Gillingham United Kingdom | X | |||||||||||
Thermo Fisher Scientific Baltics UAB V.A.Graiciuno 8 LT-02241 Vilnius Lithuania | X | |||||||||||
o | TÜV SÜD Iberia S.A.U. Ronda Can Fatjó 13 08290 Cerdanyola del Vallès Barcelona Spain | X | ||||||||||
VWR International BVBA Haasrode Researchpark 2020 3001 Leuven Belgium | X | |||||||||||
o | WILLAND INTERNATIONAL LTD 11 WINDSOR ROAD SL9 7NB GERRARDS CROSS Bucks United Kingdom | X | ||||||||||
[Confidential] [Confidential] |
Administrative data open all close all
- 01-2119957659-16-0000
- 01-2119957659-16-0001
- 01-2119957659-16-0002
- 01-2119957659-16-0003
- 01-2119957659-16-0004
- 01-2119957659-16-0005
- 01-2119957659-16-0006
- 01-2119957659-16-0009
- 01-2119957659-16-0010
- 01-2119957659-16-0011
- 01-2119957659-16-0012
- 01-2119957659-16-0013
- 01-2119957659-16-0014
- 01-2119957659-16-0015
- 01-2119957659-16-0016
- 01-2119957659-16-0017
- 01-2119957659-16-0018
- 01-2119957659-16-0019
- 01-2119957659-16-0020
- 01-2119957659-16-0021
- 01-2119957659-16-0022
- 01-2119957659-16-0023
- 01-2119957659-16-0024
- 01-2119957659-16-0025
- 01-2119957659-16-0026
- 01-2119957659-16-0027
- 01-2119957659-16-0028
- 01-2119957659-16-0029
- 01-2119957659-16-0030
- 01-2119957659-16-0031
- 01-2119957659-16-0032
- 01-2119957659-16-0033
- 01-2119957659-16-0034
- 01-2119957659-16-0035
- 01-2119957659-16-0036
- 01-2119957659-16-0037
- [Confidential]
Contact Persons responsible for the SDS open all close all
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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