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EC number: 212-454-9
CAS number: 818-61-1
In a prenatal developmental toxicity study, Hydroxyethyl
acrylate was administered to pregnant New Zealand White rabbits
daily by stomach tube from implantation to one day prior to the expected
day of parturition (GD 6-28).
Analyses confirmed the correctness of the
prepared concentrations and the stability of the test substance in the
Clinical examinations revealed no
toxicologically relevant difference between the animals receiving 6 or
20 mg/kg bw/d Hydroxyethyl acrylate and the controls.
At the high-dose level of 60 mg/kg bw/d
slightly, but consistently lower food consumption as well as lower body
weight gain during the first two treatment weeks may represent beginning
signs of maternal toxicity.
Concerning clinical pathology, no
treatment-related, adverse effects were observed up to a dose of the
compound of 60 mg/kg bw/d.
Regarding pathology, all findings occurred
either individually or were biologically equally distributed over
control and treatment groups. They were considered to be incidental or
spontaneous in origin and without any relation to treatment.
There were no test substance-related and/or
biologically relevant differences between the different test groups in
conception rate, in the mean number of corpora lutea and implantation
sites or in the values calculated for the pre- and postimplantation
losses, the numbers of resorptions and viable fetuses. Similarly, no
influence of the test substance on uterine weight, placental weight,
fetal weight and sex distribution of the fetuses was noted at any dose.
All differences observed are considered to reflect the normal range of
fluctuations for animals of this strain and age.
Fetal examinations revealed no
toxicologically relevant adverse effects of the test substance on
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