Registration Dossier
Registration Dossier
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EC number: 212-454-9 | CAS number: 818-61-1
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- Basic data given, no information on purity, vapour or aerosol
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 951
Materials and methods
- Principles of method if other than guideline:
- The test was conducted according to the method described by Smyth & Carpenter (1948).
Smyth & Carpenter (1948). J. Indust. Hyg. & Toxicol. 30: 63 - GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2-hydroxyethyl acrylate
- EC Number:
- 212-454-9
- EC Name:
- 2-hydroxyethyl acrylate
- Cas Number:
- 818-61-1
- Molecular formula:
- C5H8O3
- IUPAC Name:
- 2-hydroxyethyl acrylate
- Test material form:
- not specified
- Details on test material:
- not specified
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 2-Hydroxyethyl acrylate
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Route of administration:
- other: vapour/aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 4 h
- Concentrations:
- 500 ppm (corresponding to approx. 2.4 mg/L)
Recalculation based on the equation c(mg/m3) = molar mass (g) / molar volume (L) x c(mL/m3) with molecular weight (116.12 g/mol) and molar volume (24.1 L at 20 °C and 1013 hPa) [DFG, MAK List, Wiley-VCH Verlag, 2008]. - No. of animals per sex per dose:
- 6
- Control animals:
- not specified
Results and discussion
- Mortality:
- Exposure to 500 ppm (2.4 mg/L) for 4 hours was lethal for 5 out of 6 animals.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
