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EC number: 212-454-9
CAS number: 818-61-1
The average 14C-HEA doses (mg/kg bw)
administered to the dermal treatment group ranged from 84 % to 107 % of
No signs of toxicity were observed following
dermal administration. In addition, at 48 hr post-dermal application
there was an absence of skin irritation.
Since an average of only 66 % of the applied
dermal dose was absorbed within 48 hr post-dosing, the dermal absorption
of 14C-HEA was a relatively slow process.
The data show, that once systemically
available, HEA is rapidly metabolized and eliminated from the body.
Following the 12.5 mg/kg dermal dose, the
half-life for the terminal phase of elimination via 14CO2 was determined
to be approximately 17 hr. The half-life for the initial phase of
elimination was 4.9.
For the dermal route of administration the
half-life of elimination in the urine was approximately 14 hr.
The blood concentration-time profile
following dermal administration showed a slow rise in 14C blood
concentrations from 15 min post-dosing to peak at 12 hr postdosing,
suggesting a slow rate of dermal absorption. However, following dermal
absorption the plasma radioactivity concentration-time profile was
monophasic suggesting a first order process of elimination. The terminal
half-life for the disappearance of plasma 14C activity following dermal
dosing was 45 hr. However, this may actually represent the half-life for
of radioactivity 48 hr after exposure:
12.5 mg/kg bw
27.38 ± 3.06
0.59 ± 0.41
Tissues & carcass
9.19 ± 0.93
26.53 ± 2.73
0.36 ± 0.45
0.70 ± 0.28
32.80 ± 6.16
97.54 ± 1.06
Percent of dose
represent Mean ± SD for 4 animals.
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