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EC number: 212-454-9
CAS number: 818-61-1
Table: Summary of cell density, area
under growth curves and growth rate for the definitive test:
Nominal conc. (mg/L)
Average Cell Counts (x10000)
Inhibition of biomass %
Growth Rate-related Inhibition %
ADDITIONAL EFFECT VALUES
Inhibition of Biomass (area under the
EbC50 (96h) = 4.12 mg/L (95% CI = 3.75
- 4.52 mg/L)
LOEC (72h) = 1.25 mg/L
NOEC (96h) = 0.625 mg/L
LOEC (96h) = 1.25 mg/L
Inhibition of Growth:
ErC50 (96h) = 8.26 mg/L (95% CI = 7.62
- 8.95 mg/L)
LOEC (72h) = 2.5 mg/L
NOEC (96h) = 2.5 mg/L
LOEC (96h) = 5.0 mg/L
ErC50 = 6 mg/L mg/L (Pseudokirchnerella
NOErC = 1 mg/L (Pseudokirchnerella
Two studies are available that
assessed the toxicity of 2-hydroxyethyl acrylate to freshwater algae.
Further, data of a close structural analogue (CAS 25584-83-2) is
available and used as supporting information.
The acute toxicity of 2-hydroxyethyl
acrylate to aquatic algae was investigated according to OECD Guideline
201. After 72 hours of exposure to Pseudokirchnerella subcapitata
an ErC50 of 6 mg/L was measured using the growth rate as endpoint (MOE,
1998). Although no detailed test report is available, all tests from the
Japanese Authorities are performed according to OECD guidelines and GLP. Also,
data on a second study is available, the 72-h EC50 and NOEC
values were determined to be 8.81 mg/L and 1.25 mg/L, respectively (HEA/HPAConsortium,
In the study with the structural
analogue 2 -hydroxypropyl acrylate an ErC50 (72h) of 6.98 mg/L based on
growth was determined.
Overall, the lowest determined
effect values of 6 mg/L (ErC50) and 1 mg/L (NOErC) (MOE, 1998) will be
used as key value for the chemical safety assessment for freshwater
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