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EC number: 212-454-9
CAS number: 818-61-1
Table: Cumulative Immobility
Mean measured concentration (mg/L)
Number of Immobile
ADDITIONAL EFFECT VALUE
24-h EC50 value: 13.4 mg/L (95% C.L.: 11.5 -
The 48-h EC50 value is 9.3 mg/L in aquatic
invertebrates (Daphnia magna).
Two studies are available that
assessed the acute toxicity of 2-hydroxyethyl acrylate to aquatic
invertebrates. Further, data of a close structural analogue (CAS
25584-83-2) is available and used as supporting information.
In the first study, the acute toxicity
was determined according to OECD TG 202 and in compliance with GLP
criteria (Wildlife International, 2013). In this study, daphnids (D.
magna, 20 per concentration) were exposed to nominal concentrations of 0
(control), 0 (vehicle control), 3.9, 6.5, 11, 18, 30 mg/L for 48 hours
under flow-through conditions (5 volume additions of test water in each
test chamber per day). Analytical confirmation of nominal test
concentrations showed that all test concentrations remained within ±20%
of nominal concentrations throughout the test. Nevertheless, effect
concentrations are expressed as measured (arithmetic mean).
Immobilization was recorded after 3, 24 and 48 hours exposure. Percent
immobility at test termination in the 3.4, 6.2, 10, 17 and 29 mg/L mean
measured treatment groups was 0, 5, 60, 100 and 100% after 48 hours
exposure, respectively. Based on these results, the 48-h EC50 was
determined to be 9.3 mg/L.
In another study according to OECD TG
202, an EC50 of 5.2 mg/L based on measured concentrations was determined
for Daphnia magna after 48 hours of exposure (MOE, 1998). Although no
detailed test report is available, all tests from the Japanese
Authorities are performed according to OECD guidelines and GLP.
These results are supported by data
from the structural analogue 2-hydroxypropyl acrylate (2-HPA). In an
acute toxicity study conducted according to OECD guideline 202 in
Daphnia magna with 2-HPA, an EC50 of 24 mg/L based on nominal test
concentrations was determined (Dow 1992).
Overall, the effect value of 48-h EC50
value of 9.3 mg/L was selected as key value for the chemical safety
assessment, as it is considered the most reliable result (derived in a
GLP-compliant study that followed standard guidelines, the daphnids in
this study were exposed under flow-through condtitions and the effect
value is based on measured concentrations).
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