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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

The key skin irritation/corrosion study found a 65% aqueous solution of CHPTAC to be non-irritant when in semi-occluded contact with rabbit skin for 4 h.
The key eye irritation/corrosion study reported transient irritation in rabbit eyes treated with a 65% aqueous solution of CHPTAC.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Additional information

The key skin irritation study (Shell, 1987) was chosen from six studies, generating a similar classification, as the most recent study. The key study was of reliability 2 and the supporting studies comprised three of reliability 2 (reliable with restrictions; an absence of GLP) and two of reliability 4 (not assignable; very limited reports).

The key eye irritation/corrosion study was identified from seven giving broadly similar findings as the most recent study. The key study was of reliability 2. Supporting studies (3 each of reliability 2 and 4), indicated that the test material (55% or 60% CHPTAC or unspecified) was either slightly irritant or non-irritant. One study (QUAS048, reliability 2) produced results that were judged at the time to indicate a non-irritant material but which by the most recent EU criteria (2008) might just be considered a Category 2 eye irritant. The balance of findings from other studies (many of good quality) are that the test material (up to 65% CHPTAC, where specified) would not be classified as an eye irritant.

In the case of skin and eye irritation, it is not possible from the data identified to determine what the effect of the pure (100%) material might be.

Justification for classification or non-classification

The available data do not support classification for skin irritation/corrosion.

The available data do not support classification for eye irritation, but see discussion above.