Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 201-114-5 | CAS number: 78-40-0
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: artificial skin model - validity for human skin not evident
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Chemical structure and skin penetrating capacity of a short series of organic phosphates and phosphoric acid
- Author:
- Marzulli F, Callahan JF, Brown DWC
- Year:
- 1 965
- Bibliographic source:
- J Invest Derm, 44, 339-344
- Reference Type:
- publication
- Title:
- Die Durchlaessigkeit der Haut fuer ausgewaehlte aliphatische und alicyclische Traegersubstanzen
- Author:
- Meyer F, Meyer E, Kerk L
- Year:
- 1 959
- Bibliographic source:
- Arzneim Forsch 9, 430-432 (1959) cited in BUA report no 37
- Reference Type:
- review article or handbook
- Title:
- Triethylphosphat BUA Stoffbericht 37 (Maerz 1989)
- Year:
- 1 989
- Bibliographic source:
- Beratergremium für umweltrelevante Altstoffe (BUA) d. Ges. Dt. Chemiker, Weinheim, Basel (Schweiz), Cambridge, New York, NY: VCH 1989 (Bua Stoffbericht 37)
Materials and methods
- Principles of method if other than guideline:
- The skin penetrating capacities of a series of organic phosphates were measured by using a skin model in which isolated anterior forearm stratum corneum conjunctum was used
- GLP compliance:
- no
Test material
- Reference substance name:
- Triethyl phosphate
- EC Number:
- 201-114-5
- EC Name:
- Triethyl phosphate
- Cas Number:
- 78-40-0
- Molecular formula:
- C6H15O4P
- IUPAC Name:
- triethyl phosphate
- Details on test material:
- no data
Constituent 1
- Radiolabelling:
- yes
- Remarks:
- 32P labeled compound were used
Test animals
- Species:
- other: not applicable - in vitro method was used
- Strain:
- other: not applicable - in vitro method was used
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- no data
- Doses:
- no data
- No. of animals per group:
- not applicable - in vitro method was used
- Control animals:
- no
Results and discussion
- Conversion factor human vs. animal skin:
- no data
Any other information on results incl. tables
The average maximum steady-state rate of penetration through isolated human skin is 0.623 x 10² µmol/cm² per min.
Applicant's summary and conclusion
- Executive summary:
The skin penetranting capacities of a series of organic phosphates were measured by using a skin model in which isolated anterior forearm stratum corneum conjunctum was used.
The average maximum steady-state rate for triethyl phosphate of penetration through isolated human skin is 0.623 x 10² µmol/cm² per min.
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