Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-900-5 | CAS number: 75-77-4
Endpoint summary
Administrative data
Description of key information
In a well conducted skin irritation study conducted according to OECD test guideline 404 (GLP status not known) trimethylchlorosilane was corrosive to the skin of rabbits (Bayer AG 1985). In the key eye irritation study 0.1 ml of chlorotrimethylsilane was severely irritating to the eyes (BRRC 1982). Based on the findings of acute inhalation sudies, chlorotrimethylsilane is irritating to the respiratory tract (Jean 1999).
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
The most reliable studies were selected as the key studies. Where there was more than one study with the same reliability score (i.e. skin irritation), the most recent study was selected as the key study. The studies for eye irritation showed on balance that trimethylsilanol is corrosive to the eyes. Chlorotrimethylsilane is rapidly hydrolysed to methylsilanediol and hydrogen chloride in the presence of moisture. Therefore signs of skin and eye irritation/corrosion are due to the hydrolysis product HCl.
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Effect level: empty Endpoint conclusion: Adverse effect observed
Justification for classification or non-classification
The test substance is labelled R35-37, 'Causes severe burns', 'Irritating to eyes' and 'Irritating to respiratory system' under Directive 67/548/EEC and 'Skin Corr. 1A' under Regulation 1272/2008. This is based on the skin irritation/corrosion data that show the test substance to be clearly corrosive to the skin. It is assumed that substances that are corrosive to the skin are also damaging to the eyes, so there is no separate labelling for the eyes (hazard statement H314 is required). There are no specific data for respiratory irritation. However, the pathology examination in the key acute inhalation study revealed signs of respiratory irritation/corrosion. The hazard statement 'EUH071 Corrosive to the respiratory tract' is proposed on the basis of effects observed following exposure via the acute inhalation route.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
