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Diss Factsheets
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EC number: 912-664-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Toxicity to birds
Administrative data
- Endpoint:
- short-term toxicity to birds: acute oral toxicity test
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Already evaluated by the Competent Authorities for Biocides and Existing Substance Regulations.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
Materials and methods
- Principles of method if other than guideline:
- The doses were administered as a single sose via gavage with the test substance suspended in Tylose (CMC) with each dose adjusted to the individual body weights of the birds. Birds were weighed predose and on day 14 post dose.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Dicopper oxide
- EC Number:
- 215-270-7
- EC Name:
- Dicopper oxide
- Cas Number:
- 1317-39-1
- Molecular formula:
- Cu2O
- IUPAC Name:
- Copper(I)oxide
- Details on test material:
- Cu2O was suspended in Tylose
Constituent 1
- Dose method:
- gavage
- Vehicle:
- yes
- Details on preparation and analysis of diet:
- Cu2O was suspended in Tylose and provided by gavage using a non-flexible stomach tube
Test organisms
- Test organisms (species):
- Colinus virginianus
Study design
- Limit test:
- no
- Total exposure duration (if not single dose):
- 14 d
- Post exposure observation period:
- see study summary
- No. of animals per sex per dose and/or stage:
- 20 males and 20 females
- Control animals:
- no
- Nominal and measured doses / concentrations:
- 1000,1300,1600 and 2000 mg/kg body weight
doses adjusted to administer 1 ml/animal
Examinations
- Details on examinations and observations:
- mortality , body weight, behavior, post-mortum
- Details on reproductive parameters:
- not assessed
- Reference substance (positive control):
- no
Results and discussion
Effect levels
- Duration (if not single dose):
- 14 d
- Dose descriptor:
- other: see summary
- Effect level:
- ca. 1 400 mg/kg bw
- Conc. / dose based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: see summary
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The study results into an LD50 of 1400 mg/kg body wt.
Cu2O was administered in Tylose to enhance adsorption and through gavage.
This procedure therefore by-passes normal copper homeostasis. - Executive summary:
OECD Guidelines No. 401 (May 1981)Birds were purchased from a commercial source for use in the definitive study. Birds were weighed predose and on day 14 post dose. The doses were administered via gavage with the test substance suspended in Tylose (CMC) with each dose adjusted to the individual body weights of the birds. Food and water were availablead libitumduring the study. Food consumption was not reported. The birds were subjected to 12 hours light and 12 hours dark daily. Temperature and relative humidity were monitored and kept within a narrow range. The birds were observed daily for adverse effects. No mortality was noted during either the range finder or the definitive study. After 14 days the survivors were sacrificed and subjected to macroscopic examination.
The 24 hour and 14 day LC50s are presented in 5.2.1 below. The slopes the 7 and 14 day data are identical and show as a single line on the mortality curve in 4.2.5 above. The slope of the 24 hour curve is 1.36 and the slope of the 14 day curve is 1.30. During post mortem and final autopsies, no anatomical-pathological findings were noted in the thorax or cranial cavities. In the abdomen, there was hyperaemia of the gastrointestinal tract of the acute mortalities.
Additional adverse effects are summarized as follows:
1000 mg/kg – frightened up to 5 days, reduced reflexes through day 7, ruffled feathers, greasy mucosae, soft and greasy faeces, normal food consumption and weight gains, acute symptoms, sedation and incoordination.
1300 mg/kg – apathy til frightened, clearly diminished reflexes, dirty and bristled feathers, greasy mucosae, soft and greasy faeces, reduced food and water consumption and weight gains, acute symptoms, sedation, ruffled, tremor, titubation, abdominal ache, one acute and one delayed mortality.
1600 mg/kg – apathy til frightened, clearly diminished reflexes, dirty and bristled feathers, greasy mucosae, soft and greasy faeces, clearly reduced food and water consumption and weight gains, acute symptoms, sedation, ruffled, tremor, titubation, abdominal ache, seven acute and two delayed mortalities.
1600 mg/kg – all animals died within 24 hours of treatment, acute symptoms, sedation, tremor, titubation, abdominal ache, exohthalmos, and exitus, ten acute mortalities.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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