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Diss Factsheets
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EC number: 202-617-2 | CAS number: 97-90-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction
1. SOFTWARE
no software used
2. MODEL (incl. version number)
The prediction model used in this investigation for a set of methacrylate chemicals is based on an established model (Potts and Guy, 1992).
3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
not stated in report
4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
The “Relative Dermal Absorption” potential assigned to the predicted skin flux for methacrylate data is an arbitrary estimation of skin penetration potential, and is not a regulatory or OECD approved classification. It is based on several hundred chemicals tested in the same human skin model at the Central Toxicology Laboratory and Dermal Technology Laboratory. This database includes a wide variety of pharmaceutical, agrochemical and industrial chemicals tested over a 20 year period. The dermal absorption potential of a particular chemical substance is placed into one of six categories based on its skin permeability coefficient or its predicted (or actual) absorption rate
5. APPLICABILITY DOMAIN
not explicitely stated in the report
6. ADEQUACY OF THE RESULT
not explicitely stated in the report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
- Principles of method if other than guideline:
- Prediction of the skin penetration characteristics using the physicochemical properties used as a first level assessment of the ability of chemical to cross the human epidermis based on: Potts RO and Guy RH (1992). Predicting Skin Permeability. Pharm. Res. 9(5): 663-669
- GLP compliance:
- no
Test material
- Reference substance name:
- Ethylene dimethacrylate
- EC Number:
- 202-617-2
- EC Name:
- Ethylene dimethacrylate
- Cas Number:
- 97-90-5
- Molecular formula:
- C10H14O4
- IUPAC Name:
- 2-[(2-methylprop-2-enoyl)oxy]ethyl 2-methylprop-2-enoate
Constituent 1
Test animals
- Species:
- other: human skin QSAR
- Details on test animals or test system and environmental conditions:
- Prediction of the skin penetration characteristics using the physicochemical properties used as a first level assessment of the ability of chemical to cross the human epidermis based on: Potts RO and Guy RH (1992). Predicting Skin Permeability. Pharm. Res. 9(5): 663-669
Assumed skin temperature: 32 °C
Results and discussion
Any other information on results incl. tables
Chemical Class |
Test Chemical / Compound Identity |
Acronym |
Molecular Weight |
Log P |
Predicted Flux (µg/cm2/h) |
Relative Dermal Absorption |
Multi-func aliph/hydrophob DMA |
Ethylene glycol dimethacrylate |
EGDMA |
198.22 |
2.4 |
6.109 |
Low |
Applicant's summary and conclusion
- Conclusions:
- Based on the dermal penetration model for human skin the predicted skin penetration for EGDMA is low (6.109 µg/cm²/h).
- Executive summary:
Based on the dermal penetration model for human skin the predicted skin penetration for EGDMA is low (6.109 µg/cm²/h).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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