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EC number: 203-941-7 | CAS number: 112-16-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study is comparable to OECD 403 (inhalation risk test) with acceptable restrictions mostly due to reduced reporting in times before GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 968
- Report date:
- 1968
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- other:
- Limit test:
- yes
Test material
- Reference substance name:
- Lauroyl chloride
- EC Number:
- 203-941-7
- EC Name:
- Lauroyl chloride
- Cas Number:
- 112-16-3
- Molecular formula:
- C12H23ClO
- IUPAC Name:
- dodecanoyl chloride
- Reference substance name:
- XVIII/195
- IUPAC Name:
- XVIII/195
- Details on test material:
- - Name of test material (as cited in study report): Laurylsaeurechlorid
- Physical state: liquid
- Purity: no data
- Expiration date of the lot/batch: not reported
- Stability under test conditions: not reported
- Storage condition of test material: not reported
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Mean weight per trial at study initiation: 171 and 167 g (mixed sexes)
no further details given
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- Rats were exposed for 8 h to a vapour saturated atmosphere.
The vapour was generated by bubbling 200 l/h dry air (no CO2) through the liquid substance column (volume ca. 50 ml) of about 5 cm above a fritted glass disc in a glass cylinder. The glass cylinder was heated in a water bath. Temperature in the exposure chamber was 20°C. Nominal concentration was stated in the raw data to be 0.15 mg/L (0.156 mg/l as recalculated from the raw data).
The vapour saturation treshold is calculated to be approx. 0.21 mg/L (at 25°C). Therefor, the test atmosphere should be considered as vapour. - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 8 h
- Concentrations:
- Nominal concentration was 0.16 mg/L as mean of two trials with 0.11 and 0.21 mg/L, respectively
- No. of animals per sex per dose:
- 6 (3 animals/sex in two trials)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: Weighing was performed at the start and at the end of the study. Observation was several times at the day of exposure and presumably daily on the following days except on weekends and holidays.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Statistics:
- none
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- > 0.16 mg/L air (nominal)
- Exp. duration:
- 8 h
- Remarks on result:
- other: No mortality observed within 8 h
- Mortality:
- No mortality observed
- Clinical signs:
- other: (Slight) irritations of the mucosa, closed eye lids; reversible within 1 d
- Body weight:
- Mean body weight after 7 d
1st trial 192 g (weight gain +21 g); 2nd trial 183 g (+17 g) - Gross pathology:
- Chronic bronchitis (2x), blown lung (1x)
Applicant's summary and conclusion
- Executive summary:
Study is comparable with the inhalation hazard test described in the Annex of OECD Guideline 403 (adopted 1981) with acceptable restrictions mostly due to reduced reporting in times before GLP. Rats were exposed for 8 h to a vapour saturated atmosphere. nominal concentration was 0.16 mg/L as stated in the raw data. No mortality was reported; observed clinical signs and necropsy findings were irritation effects on the mucosa and blown lung (in one case), respectively.
Conclusion
Inhalation of 0.16 mg/L Lauroyl chloride for 8 h does not represent a lethal inhalation risk.
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