Registration Dossier
Registration Dossier
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EC number: 203-941-7 | CAS number: 112-16-3
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
Parent compound lauroyl chloride and hydrolysis product lauric acid: The substance and its hydrolysis product do not significantly accumulate in organism.
However, the assessment of the bioaccumulation potential of the parent compound may be of low relevance due to the rapid hydrolysis of the acid chloride in aqueous solutions.
Key value for chemical safety assessment
- BCF (aquatic species):
- 252 L/kg ww
Additional information
A study is not required for this tonnage band.
Experimental data are available only for the structurally similar substance sodium laurate (CAS 629 -25 -4). In a study similar to OECD 305E using Danio rerio as test organism, the BCF was determined to be 252 ± 19 L/kg (conc. 2.0 to 3.6 mg/L, nominal; Van Egmond et al., 1999; also cited in ECHA, 2012). The study was selected as key study although some deficiencies were detected (e.g., steady state only assumed based on log Kow, sampling of fish only at end of exposure, depuration phase not studied).
In addition QSAR estimates were calculated for lauroyl chloride and its degradation product lauric acid (CAS 143 -07 -7).
Lauroyl chloride (CAS 112 -16 -3):
1) EPI Suite v4.10 SRC BCFBAF v3.01: BCF = 16.7 L/kg ww (log BCF = 1.22).
The obtained BCF value indicates that no significant accumulation in organisms is expected. However, the calculation may be of low relevance, as the acid chloride decomposes in aqueous solutions within 10 minutes and forms lauric acid (CAS 143 -07 -7) and hydrochloric acid.
Lauric acid (CAS 143 -07 -7):
2) EPI Suite v4.10 SRC BCFBAF v3.01: BCF = 3.2 L/kg ww (log BCF = 0.50).
3) CATALOGIC v5.11.1, BCF - new ionization term model: BCF (without mitigating factors)= 5184 L/kg ww; BCF (with mitigating factors) = 228 L/kg ww
4) CATALOGIC v5.10.8 Baseline model: BCF (without mitigating factors) = 2675 L/kg ww, BCF (with mitigating factors) = 19.4 L/kg ww
The BCF is reduced significantly if mitigating factors such as substance type (acids) and metabolism are considered.
Based on the available experimental and QSAR data, the substance does not significantly accumulate in organisms (BCF < 500).
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